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Research Article

Control of Muscle Mitochondria by Insulin Entails Activation of Akt2-mtNOS Pathway: Implications for the Metabolic Syndrome

  • Paola Finocchietto,

    Affiliations: Laboratory of Oxygen Metabolism, University Hospital, Buenos Aires, Argentina, Department of Medicine, University Hospital, University of Buenos Aires, Buenos Aires, Argentina

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  • Fernando Barreyro,

    Affiliations: Laboratory of Oxygen Metabolism, University Hospital, Buenos Aires, Argentina, Department of Medicine, University Hospital, University of Buenos Aires, Buenos Aires, Argentina

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  • Silvia Holod,

    Affiliations: Laboratory of Oxygen Metabolism, University Hospital, Buenos Aires, Argentina, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry, University Hospital, University of Buenos Aires, Buenos Aires, Argentina

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  • Jorge Peralta,

    Affiliations: Laboratory of Oxygen Metabolism, University Hospital, Buenos Aires, Argentina, Department of Medicine, University Hospital, University of Buenos Aires, Buenos Aires, Argentina

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  • María C. Franco,

    Affiliation: Laboratory of Oxygen Metabolism, University Hospital, Buenos Aires, Argentina

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  • Carlos Méndez,

    Affiliation: Department of Human Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina

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  • Daniela P. Converso,

    Affiliation: Laboratory of Oxygen Metabolism, University Hospital, Buenos Aires, Argentina

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  • Alvaro Estévez,

    Affiliation: Burke Medical Research Institute, Cornell University, Ithaca, New York, United States of America

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  • Maria C. Carreras,

    Affiliations: Laboratory of Oxygen Metabolism, University Hospital, Buenos Aires, Argentina, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry, University Hospital, University of Buenos Aires, Buenos Aires, Argentina

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  • Juan J. Poderoso mail

    To whom correspondence should be addressed. E-mail: jpoderos@fmed.uba.ar

    Affiliations: Laboratory of Oxygen Metabolism, University Hospital, Buenos Aires, Argentina, Department of Medicine, University Hospital, University of Buenos Aires, Buenos Aires, Argentina

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  • Published: March 12, 2008
  • DOI: 10.1371/journal.pone.0001749

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