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Open Access
Peer-reviewed
Research Article
Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index
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Marie-José C. van Lierop ,
Contributed equally to this work with: Marie-José C. van Lierop, Wynand Alkema
* E-mail: mariejose.vanlierop@merck.com
Affiliation Department of Immune Therapeutics, MSD, Oss, The Netherlands
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Wynand Alkema ,
Contributed equally to this work with: Marie-José C. van Lierop, Wynand Alkema
Affiliation Department of Molecular Design and Informatics, MSD, Oss, The Netherlands
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Anke J. Laskewitz,
Affiliation Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands
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Rein Dijkema,
Affiliation Molecular Pharmacology Department, MSD, Oss, The Netherlands
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Hans M. van der Maaden,
Affiliation Molecular Pharmacology Department, MSD, Oss, The Netherlands
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Martin J. Smit,
Affiliation Molecular Pharmacology Department, MSD, Oss, The Netherlands
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Ralf Plate,
Affiliation Medicinal Chemistry Department, MSD, Oss, The Netherlands
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Paolo G. M. Conti,
Affiliation Medicinal Chemistry Department, MSD, Oss, The Netherlands
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Christan G. J. M. Jans,
Affiliation Medicinal Chemistry Department, MSD, Oss, The Netherlands
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C. Marco Timmers,
Affiliation Women's Health Department, MSD, Oss, The Netherlands
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Constant A. A. van Boeckel,
Affiliation Medicinal Chemistry Department, MSD, Oss, The Netherlands
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Scott J. Lusher,
Affiliation Department of Molecular Design and Informatics, MSD, Oss, The Netherlands
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Ross McGuire,
Affiliation Department of Molecular Design and Informatics, MSD, Oss, The Netherlands
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Rene C. van Schaik,
Affiliation Department of Molecular Design and Informatics, MSD, Oss, The Netherlands
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Jacob de Vlieg,
Affiliation Department of Molecular Design and Informatics, MSD, Oss, The Netherlands
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Ruben L. Smeets,
Affiliation Department of Immune Therapeutics, MSD, Oss, The Netherlands
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Claudia L. Hofstra,
Affiliation Department of Immune Therapeutics, MSD, Oss, The Netherlands
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Annemieke M. H. Boots,
Affiliation Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
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Marcel van Duin,
Affiliation Women's Health Department, MSD, Oss, The Netherlands
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Benno A. Ingelse,
Affiliation Toxicology and Drug Disposition, MSD, Oss, The Netherlands
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Willem G. E. J. Schoonen,
Affiliation Toxicology and Drug Disposition, MSD, Oss, The Netherlands
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Aldo Grefhorst,
Affiliation Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands
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Theo H. van Dijk,
Affiliation Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands
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Folkert Kuipers,
Affiliations Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands, Department of Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
⨯ - [ ... ],
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Wim H. A. Dokter
Affiliation Department of Immune Therapeutics, MSD, Oss, The Netherlands
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Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index
- Marie-José C. van Lierop,
- Wynand Alkema,
- Anke J. Laskewitz,
- Rein Dijkema,
- Hans M. van der Maaden,
- Martin J. Smit,
- Ralf Plate,
- Paolo G. M. Conti,
- Christan G. J. M. Jans,
- C. Marco Timmers
- Published: November 12, 2012
- https://doi.org/10.1371/journal.pone.0048385