Amyloid-β and Proinflammatory Cytokines Utilize a Prion Protein-Dependent Pathway to Activate NADPH Oxidase and Induce Cofilin-Actin Rods in Hippocampal Neurons

• Keifer P. Walsh ,

  Contributed equally to this work with: Keifer P. Walsh, Laurie S. Minamide, Thomas B. Kuhn

  Affiliation Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, United States of America

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• Laurie S. Minamide ,

  Contributed equally to this work with: Keifer P. Walsh, Laurie S. Minamide, Thomas B. Kuhn

  Affiliation Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, United States of America

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• Sarah J. Kane,

  Affiliations Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, United States of America, Molecular, Cellular and Integrative Neuroscience Program, Colorado State University, Fort Collins, Colorado, United States of America

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• Alisa E. Shaw,

  Affiliation Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, United States of America

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• David R. Brown,

  Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

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• Bruce Pulford,

  Affiliation Prion Research Center, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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• Mark D. Zabel,

  Affiliations Molecular, Cellular and Integrative Neuroscience Program, Colorado State University, Fort Collins, Colorado, United States of America, Prion Research Center, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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• J. David Lambeth,

  Affiliation Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, United States of America

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• Thomas B. Kuhn ,

  Contributed equally to this work with: Keifer P. Walsh, Laurie S. Minamide, Thomas B. Kuhn

  Affiliations Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, United States of America, Department of Chemistry and Biochemistry, University of Alaska, Fairbanks, Alaska, United States of America

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• James R. Bamburg

  * E-mail: James.Bamburg@ColoState.edu

  Affiliations Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, United States of America, Molecular, Cellular and Integrative Neuroscience Program, Colorado State University, Fort Collins, Colorado, United States of America

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