Melittin Restores PTEN Expression by Down-Regulating HDAC2 in Human Hepatocelluar Carcinoma HepG2 Cells

Hui Zhang; Bin Zhao; Cheng Huang; Xiao-Ming Meng; Er-Bao Bian; Jun Li

doi:10.1371/journal.pone.0095520

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Research Article

Melittin Restores PTEN Expression by Down-Regulating HDAC2 in Human Hepatocelluar Carcinoma HepG2 Cells

Hui Zhang ,

Contributed equally to this work with: Hui Zhang, Bin Zhao

Affiliations School of pharmacy, Anhui key laboratory of bioactivity of natural products, Anhui Medical University, Hefei, Anhui Province, China, Institute for Liver Diseases of Anhui Medical University (AMU), Hefei, Anhui Province, China
⨯
Bin Zhao ,

Contributed equally to this work with: Hui Zhang, Bin Zhao

Affiliations School of pharmacy, Anhui key laboratory of bioactivity of natural products, Anhui Medical University, Hefei, Anhui Province, China, Institute for Liver Diseases of Anhui Medical University (AMU), Hefei, Anhui Province, China
⨯
Cheng Huang,

Affiliations School of pharmacy, Anhui key laboratory of bioactivity of natural products, Anhui Medical University, Hefei, Anhui Province, China, Institute for Liver Diseases of Anhui Medical University (AMU), Hefei, Anhui Province, China
⨯
Xiao-Ming Meng,

Affiliations School of pharmacy, Anhui key laboratory of bioactivity of natural products, Anhui Medical University, Hefei, Anhui Province, China, Institute for Liver Diseases of Anhui Medical University (AMU), Hefei, Anhui Province, China
⨯
Er-Bao Bian,

Affiliations School of pharmacy, Anhui key laboratory of bioactivity of natural products, Anhui Medical University, Hefei, Anhui Province, China, Institute for Liver Diseases of Anhui Medical University (AMU), Hefei, Anhui Province, China
⨯
Jun Li

* E-mail: lj@ahmu.edu.cn

Affiliations School of pharmacy, Anhui key laboratory of bioactivity of natural products, Anhui Medical University, Hefei, Anhui Province, China, Institute for Liver Diseases of Anhui Medical University (AMU), Hefei, Anhui Province, China
⨯

Melittin Restores PTEN Expression by Down-Regulating HDAC2 in Human Hepatocelluar Carcinoma HepG2 Cells

Hui Zhang,
Bin Zhao,
Cheng Huang,
Xiao-Ming Meng,
Er-Bao Bian,
Jun Li

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Published: May 2, 2014
https://doi.org/10.1371/journal.pone.0095520

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Cell proliferation
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Hepatocellular carcinoma
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Histones
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Plasmid construction
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Small interfering RNA
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Colorectal cancer
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Cell cycle and cell division
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Lung and intrathoracic tumors
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