Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

• Valentina Escott-Price ,

  Contributed equally to this work with: Valentina Escott-Price, Céline Bellenguez, Li-San Wang, Seung-Hoan Choi, Sudha Seshadri, Gerard D. Schellenberg, Philippe Amouyel, Julie Williams

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• Céline Bellenguez ,

  Contributed equally to this work with: Valentina Escott-Price, Céline Bellenguez, Li-San Wang, Seung-Hoan Choi, Sudha Seshadri, Gerard D. Schellenberg, Philippe Amouyel, Julie Williams

  Affiliations Inserm U744, Lille, France, Université Lille 2, Lille, France, Institut Pasteur de Lille, Lille, France

  ⨯
• Li-San Wang ,

  Contributed equally to this work with: Valentina Escott-Price, Céline Bellenguez, Li-San Wang, Seung-Hoan Choi, Sudha Seshadri, Gerard D. Schellenberg, Philippe Amouyel, Julie Williams

  Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

  ⨯
• Seung-Hoan Choi ,

  Contributed equally to this work with: Valentina Escott-Price, Céline Bellenguez, Li-San Wang, Seung-Hoan Choi, Sudha Seshadri, Gerard D. Schellenberg, Philippe Amouyel, Julie Williams

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Denise Harold,

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• Lesley Jones,

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• Peter Holmans,

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• Amy Gerrish,

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• Alexey Vedernikov,

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• Alexander Richards,

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• Anita L. DeStefano,

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Jean-Charles Lambert,

  Affiliations Inserm U744, Lille, France, Université Lille 2, Lille, France, Institut Pasteur de Lille, Lille, France

  ⨯
• Carla A. Ibrahim-Verbaas,

  Affiliation Department of Epidemiology and Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands

  ⨯
• Adam C. Naj,

  Affiliation Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Rebecca Sims,

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• Gyungah Jun,

  Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America

  ⨯
• Joshua C. Bis,

  Affiliation Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America

  ⨯
• Gary W. Beecham,

  Affiliations The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America

  ⨯
• Benjamin Grenier-Boley,

  Affiliations Inserm U744, Lille, France, Université Lille 2, Lille, France, Institut Pasteur de Lille, Lille, France

  ⨯
• Giancarlo Russo,

  Affiliation Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland

  ⨯
• Tricia A. Thornton-Wells,

  Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America

  ⨯
• Nicola Denning,

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• Albert V. Smith,

  Affiliations University of Iceland, Faculty of Medicine, Reykjavik, Iceland, Icelandic Heart Association, Kopavogur, Iceland

  ⨯
• Vincent Chouraki,

  Affiliations Inserm U744, Lille, France, Université Lille 2, Lille, France, Institut Pasteur de Lille, Lille, France, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

  ⨯
• Charlene Thomas,

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• M. Arfan Ikram,

  Affiliations Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands, Netherlands Consortium for Healthy Aging, Leiden, The Netherlands

  ⨯
• Diana Zelenika,

  Affiliation Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France

  ⨯
• Badri N. Vardarajan,

  Affiliations Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America, Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America, Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America

  ⨯
• Yoichiro Kamatani,

  Affiliation Fondation Jean Dausset- CEPH, Paris, France

  ⨯
• Chiao-Feng Lin,

  Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

  ⨯
• Helena Schmidt,

  Affiliation Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria

  ⨯
• Brian Kunkle,

  Affiliation The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America

  ⨯
• Melanie L. Dunstan,

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• Maria Vronskaya,

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• the United Kingdom Brain Expression Consortium ,

  ¶Membership of the UK Brain Expression consortium is provided in Materials S1.

  Affiliation Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom

  ⨯
• Andrew D. Johnson,

  Affiliation NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, Massachusetts, United States of America

  ⨯
• Agustin Ruiz,

  Affiliation Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain

  ⨯
• Marie-Thérèse Bihoreau,

  Affiliation Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France

  ⨯
• Christiane Reitz,

  Affiliations Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America, Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America

  ⨯
• Florence Pasquier,

  Affiliations Université Lille 2, Lille, France, CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France

  ⨯
• Paul Hollingworth,

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• Olivier Hanon,

  Affiliation University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics department, Paris, France

  ⨯
• Annette L. Fitzpatrick,

  Affiliations Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Departments of Epidemiology and Global Health, University of Washington, Seattle, Washington, United States of America

  ⨯
• Joseph D. Buxbaum,

  Affiliations Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America, Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

  ⨯
• Dominique Campion,

  Affiliation CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France

  ⨯
• Paul K. Crane,

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

  ⨯
• Clinton Baldwin,

  Affiliation Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America

  ⨯
• Tim Becker,

  Affiliation German Center for Neurodegenerative Diseases (DZNE), Bonn, and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany

  ⨯
• Vilmundur Gudnason,

  Affiliations University of Iceland, Faculty of Medicine, Reykjavik, Iceland, Icelandic Heart Association, Kopavogur, Iceland

  ⨯
• Carlos Cruchaga,

  Affiliation Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America

  ⨯
• David Craig,

  Affiliation Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom

  ⨯
• Najaf Amin,

  Affiliation Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands

  ⨯
• Claudine Berr,

  Affiliation INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France

  ⨯
• Oscar L. Lopez,

  Affiliation Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Philip L. De Jager,

  Affiliations Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts, United States of America

  ⨯
• Vincent Deramecourt,

  Affiliations Université Lille 2, Lille, France, CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France

  ⨯
• Janet A. Johnston,

  Affiliation Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom

  ⨯
• Denis Evans,

  Affiliation Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America

  ⨯
• Simon Lovestone,

  Affiliation King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom

  ⨯
• Luc Letenneur,

  Affiliation Inserm U897, Victor Segalen University, F-33076, Bordeaux, France

  ⨯
• Isabel Hernández,

  Affiliation Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain

  ⨯
• David C. Rubinsztein,

  Affiliation Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

  ⨯
• Gudny Eiriksdottir,

  Affiliation Icelandic Heart Association, Kopavogur, Iceland

  ⨯
• Kristel Sleegers,

  Affiliations Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium, Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium

  ⨯
• Alison M. Goate,

  Affiliation Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America

  ⨯
• Nathalie Fiévet,

  Affiliations Inserm U744, Lille, France, Institut Pasteur de Lille, Lille, France

  ⨯
• Matthew J. Huentelman,

  Affiliation Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America

  ⨯
• Michael Gill,

  Affiliation Discipline of Psychiatry, Trinity College, Dublin, Ireland

  ⨯
• Kristelle Brown,

  Affiliation Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom

  ⨯
• M. Ilyas Kamboh,

  Affiliations Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Lina Keller,

  Affiliation Aging Reasearch Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden

  ⨯
• Pascale Barberger-Gateau,

  Affiliation King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom

  ⨯
• Bernadette McGuinness,

  Affiliation Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom

  ⨯
• Eric B. Larson,

  Affiliations Department of Medicine, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health, Seattle, Washington, United States of America

  ⨯
• Amanda J. Myers,

  Affiliation Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

  ⨯
• Carole Dufouil,

  Affiliation Inserm U897, Victor Segalen University, F-33076, Bordeaux, France

  ⨯
• Stephen Todd,

  Affiliation Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom

  ⨯
• David Wallon,

  Affiliation CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France

  ⨯
• Seth Love,

  Affiliation University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, United Kingdom

  ⨯
• Ekaterina Rogaeva,

  Affiliation Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada

  ⨯
• John Gallacher,

  Affiliation Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom

  ⨯
• Peter St George-Hyslop,

  Affiliations Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada, Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

  ⨯
• Jordi Clarimon,

  Affiliations Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain, Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain

  ⨯
• Alberto Lleo,

  Affiliations Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain, Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain

  ⨯
• Anthony Bayer,

  Affiliation Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom

  ⨯
• Debby W. Tsuang,

  Affiliation Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America

  ⨯
• Lei Yu,

  Affiliation Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America

  ⨯
• Magda Tsolaki,

  Affiliation 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece

  ⨯
• Paola Bossù,

  Affiliation Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy

  ⨯
• Gianfranco Spalletta,

  Affiliation Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy

  ⨯
• Petra Proitsi,

  Affiliation King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom

  ⨯
• John Collinge,

  Affiliation MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom

  ⨯
• Sandro Sorbi,

  Affiliations NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy, Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy

  ⨯
• Florentino Sanchez Garcia,

  Affiliation Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain

  ⨯
• Nick C. Fox,

  Affiliation Dementia Research Center, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom

  ⨯
• John Hardy,

  Affiliation Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, United Kingdom

  ⨯
• Maria Candida Deniz Naranjo,

  Affiliation Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain

  ⨯
• Paolo Bosco,

  Affiliation IRCCS Associazione Oasi Maria SS, Troina, Italy

  ⨯
• Robert Clarke,

  Affiliation Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom

  ⨯
• Carol Brayne,

  Affiliation Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge, United Kingdom

  ⨯
• Daniela Galimberti,

  Affiliation University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy

  ⨯
• Elio Scarpini,

  Affiliation University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy

  ⨯
• Ubaldo Bonuccelli,

  Affiliation Neurological Clinic, University of Pisa, Pisa, Italy

  ⨯
• Michelangelo Mancuso,

  Affiliation Neurological Clinic, University of Pisa, Pisa, Italy

  ⨯
• Gabriele Siciliano,

  Affiliation Neurological Clinic, University of Pisa, Pisa, Italy

  ⨯
• Susanne Moebus,

  Affiliation Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany

  ⨯
• Patrizia Mecocci,

  Affiliation Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy

  ⨯
• Maria Del Zompo,

  Affiliation Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy

  ⨯
• Wolfgang Maier,

  Affiliation Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany

  ⨯
• Harald Hampel,

  Affiliations Department of Psychiatry, University of Frankfurt am Main, Frankfurt am Main, Germany (H.H.), Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany

  ⨯
• Alberto Pilotto,

  Affiliation Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy

  ⨯
• Ana Frank-García,

  Affiliations Centro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid, Spain, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain, Instituto de Investigación Sanitaria “Hospital la Paz” (IdIPaz), Madrid, Spain

  ⨯
• Francesco Panza,

  Affiliation Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy

  ⨯
• Vincenzo Solfrizzi,

  Affiliation Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy

  ⨯
• Paolo Caffarra,

  Affiliations Department of Neuroscience-University of Parma, Parma, Italy, Center for Cognitive Disorders AUSL, Parma, Italy

  ⨯
• Benedetta Nacmias,

  Affiliations NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy, Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy

  ⨯
• William Perry,

  Affiliations The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America

  ⨯
• Manuel Mayhaus,

  Affiliation Department Of Psychiatry, University Hospital, Saarland, Germany

  ⨯
• Lars Lannfelt,

  Affiliation Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden

  ⨯
• Hakon Hakonarson,

  Affiliation Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

  ⨯
• Sabrina Pichler,

  Affiliation Department Of Psychiatry, University Hospital, Saarland, Germany

  ⨯
• Minerva M. Carrasquillo,

  Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

  ⨯
• Martin Ingelsson,

  Affiliation Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden

  ⨯
• Duane Beekly,

  Affiliation National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, United States of America

  ⨯
• Victoria Alvarez,

  Affiliation Genetica molecular-Huca-Oviedo, Oviedo, Spain

  ⨯
• Fanggeng Zou,

  Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

  ⨯
• Otto Valladares,

  Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

  ⨯
• Steven G. Younkin,

  Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

  ⨯
• Eliecer Coto,

  Affiliation Genetica molecular-Huca-Oviedo, Oviedo, Spain

  ⨯
• Kara L. Hamilton-Nelson,

  Affiliation The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America

  ⨯
• Wei Gu,

  Affiliation Department of Psychiatry, University Hospital, Saarland, Germany

  ⨯
• Cristina Razquin,

  Affiliation Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain

  ⨯
• Pau Pastor,

  Affiliations Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain, CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain

  ⨯
• Ignacio Mateo,

  Affiliation Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander, Spain

  ⨯
• Michael J. Owen,

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• Kelley M. Faber,

  Affiliation Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America

  ⨯
• Palmi V. Jonsson,

  Affiliations University of Iceland, Faculty of Medicine, Reykjavik, Iceland, Landspitali University Hospital, Reykjavik, Iceland

  ⨯
• Onofre Combarros,

  Affiliation Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander, Spain

  ⨯
• Michael C. O'Donovan,

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
• Laura B. Cantwell,

  Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

  ⨯
• Hilkka Soininen,

  Affiliations Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland

  ⨯
• Deborah Blacker,

  Affiliations Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Simon Mead,

  Affiliation MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom

  ⨯
• Thomas H. Mosley Jr,

  Affiliation Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, United States of America

  ⨯
• David A. Bennett,

  Affiliations Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America

  ⨯
• Tamara B. Harris,

  Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America

  ⨯
• Laura Fratiglioni,

  Affiliations Aging Research Center, Department Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden, Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden

  ⨯
• Clive Holmes,

  Affiliation Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, United Kingdom

  ⨯
• Renee F. A. G. de Bruijn,

  Affiliation Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands

  ⨯
• Peter Passmore,

  Affiliation Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom

  ⨯
• Thomas J. Montine,

  Affiliation Department of Pathology, University of Washington, Seattle, Washington, United States of America

  ⨯
• Karolien Bettens,

  Affiliations Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium, Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium

  ⨯
• Jerome I. Rotter,

  Affiliation Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America

  ⨯
• Alexis Brice,

  Affiliations INSERM UMR_S975-CNRS UMR 7225, Université Pierre et Marie Curie, Centre de recherche de l'Institut du Cerveau et de la Moëlle épinière-CRICM, Hôpital de la Salpêtrière, Paris France, AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France

  ⨯
• Kevin Morgan,

  Affiliation Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom

  ⨯
• Tatiana M. Foroud,

  Affiliation Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America

  ⨯
• Walter A. Kukull,

  Affiliation Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

  ⨯
• Didier Hannequin,

  Affiliation CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France

  ⨯
• John F. Powell,

  Affiliation King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom

  ⨯
• Michael A. Nalls,

  Affiliation Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

  ⨯
• Karen Ritchie,

  Affiliations INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France, Imperial College, London, United Kingdom

  ⨯
• Kathryn L. Lunetta,

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• John S. K. Kauwe,

  Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America

  ⨯
• Eric Boerwinkle,

  Affiliations Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America, Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas, United States of America

  ⨯
• Matthias Riemenschneider,

  Affiliation Department of Psychiatry, University Hospital, Saarland, Germany

  ⨯
• Mercè Boada,

  Affiliations Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain, Hospital Universitari Vall d'Hebron - Institut de Recerca, Universitat Autònoma de Barcelona. (VHIR-UAB), Barcelona, Spain

  ⨯
• Mikko Hiltunen,

  Affiliations Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland

  ⨯
• Eden R. Martin,

  Affiliations The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America

  ⨯
• Reinhold Schmidt,

  Affiliation Department of Neurology, Medical University Graz, Graz, Austria

  ⨯
• Dan Rujescu,

  Affiliation Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany

  ⨯
• Jean-François Dartigues,

  Affiliations Inserm U897, Victor Segalen University, F-33076, Bordeaux, France, Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France

  ⨯
• Richard Mayeux,

  Affiliations Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America, Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America

  ⨯
• Christophe Tzourio,

  Affiliation Inserm U708, Victor Segalen University, Bordeaux, France

  ⨯
• Albert Hofman,

  Affiliations Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands, Netherlands Consortium for Healthy Aging, Leiden, The Netherlands

  ⨯
• Markus M. Nöthen,

  Affiliation Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany

  ⨯
• Caroline Graff,

  Affiliations Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden, Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KIADRC, Stockholm, Sweden

  ⨯
• Bruce M. Psaty,

  Affiliations Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America

  ⨯
• Jonathan L. Haines,

  Affiliations Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America, Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America

  ⨯
• Mark Lathrop,

  Affiliations Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America, Fondation Jean Dausset- CEPH, Paris, France, McGill University and Génome Québec Innovation Centre, Montreal, Canada

  ⨯
• Margaret A. Pericak-Vance,

  Affiliations The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America

  ⨯
• Lenore J. Launer,

  Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America

  ⨯
• Christine Van Broeckhoven,

  Affiliations Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium, Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium

  ⨯
• Lindsay A. Farrer,

  Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

  ⨯
• Cornelia M. van Duijn,

  Affiliations Netherlands Consortium for Healthy Aging, Leiden, The Netherlands, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands, Center for Medical Systems Biology, Leiden, The Netherlands

  ⨯
• Alfredo Ramirez,

  Affiliation Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn, Germany

  ⨯
• Sudha Seshadri ,

  Contributed equally to this work with: Valentina Escott-Price, Céline Bellenguez, Li-San Wang, Seung-Hoan Choi, Sudha Seshadri, Gerard D. Schellenberg, Philippe Amouyel, Julie Williams

  Affiliations Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America, The Framingham Heart Study, Framingham, Massachusetts, United States of America

  ⨯
• Gerard D. Schellenberg ,

  Contributed equally to this work with: Valentina Escott-Price, Céline Bellenguez, Li-San Wang, Seung-Hoan Choi, Sudha Seshadri, Gerard D. Schellenberg, Philippe Amouyel, Julie Williams

  * E-mail: WilliamsJ@cf.ac.uk (JW); philippe.amouyel@pasteur-lille.fr (PA); gerardsc@mail.med.upenn.edu (GDS)

  Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

  ⨯
• Philippe Amouyel ,

  Contributed equally to this work with: Valentina Escott-Price, Céline Bellenguez, Li-San Wang, Seung-Hoan Choi, Sudha Seshadri, Gerard D. Schellenberg, Philippe Amouyel, Julie Williams

  * E-mail: WilliamsJ@cf.ac.uk (JW); philippe.amouyel@pasteur-lille.fr (PA); gerardsc@mail.med.upenn.edu (GDS)

  Affiliations Inserm U744, Lille, France, Université Lille 2, Lille, France, Institut Pasteur de Lille, Lille, France, CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France, Centre Hospitalier Régional Universitaire de Lille, Lille, France

  ⨯
•  [ ... ],
• Julie Williams

  Contributed equally to this work with: Valentina Escott-Price, Céline Bellenguez, Li-San Wang, Seung-Hoan Choi, Sudha Seshadri, Gerard D. Schellenberg, Philippe Amouyel, Julie Williams

  * E-mail: WilliamsJ@cf.ac.uk (JW); philippe.amouyel@pasteur-lille.fr (PA); gerardsc@mail.med.upenn.edu (GDS)

  Affiliation Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom

  ⨯
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