Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production

• Margaret M. Lowe ,

  Contributed equally to this work with: Margaret M. Lowe, Jeff E. Mold

  Affiliation Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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• Jeff E. Mold ,

  Contributed equally to this work with: Margaret M. Lowe, Jeff E. Mold

  Affiliation Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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• Bittoo Kanwar,

  Affiliations Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America, Division of Gastroenterology, Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America

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• Yong Huang,

  Affiliation Drug Studies Unit, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

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• Alexander Louie,

  Affiliation Drug Studies Unit, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

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• Michael P. Pollastri,

  Affiliation Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, United States of America

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• Cuihua Wang,

  Affiliation Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, United States of America

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• Gautam Patel,

  Affiliation Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, United States of America

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• Diana G. Franks,

  Affiliation Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, United States of America

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• Jennifer Schlezinger,

  Affiliation Department of Environmental Health, School of Public Health, Boston University, Boston, Massachusetts, United States of America

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• David H. Sherr,

  Affiliation Department of Environmental Health, School of Public Health, Boston University, Boston, Massachusetts, United States of America

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• Allen E. Silverstone,

  Affiliation Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, New York, United States of America

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• Mark E. Hahn ,

  ¶These authors also contributed equally to this work.

  Affiliation Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, United States of America

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• Joseph M. McCune

  * E-mail: mike.mccune@ucsf.edu

  ¶These authors also contributed equally to this work.

  Affiliation Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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