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Chronic Treatment with Novel Small Molecule Hsp90 Inhibitors Rescues Striatal Dopamine Levels but Not α-Synuclein-Induced Neuronal Cell Loss

  • Nikolaus R. McFarland ,

    Contributed equally to this work with: Nikolaus R. McFarland, Hemi Dimant

    nikolaus.mcfarland@neurology.ufl.edu (NRM); mclean.pamela@mayo.edu (PJM)

    Affiliation Center for Translational Research in Neurodegenerative Disease, Department of Neurology, University of Florida, Gainesville, Florida, United States of America

  • Hemi Dimant ,

    Contributed equally to this work with: Nikolaus R. McFarland, Hemi Dimant

    Affiliation MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

  • Laura Kibuuka,

    Affiliation MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

  • Darius Ebrahimi-Fakhari,

    Affiliation Division of Neurology and Inherited Metabolic Diseases, Children’s Hospital, Heidelberg University Hospital, Ruprecht-Karls University Heidelberg, Heidelberg, Germany

  • Cody A. Desjardins,

    Affiliation MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

  • Karin M. Danzer,

    Affiliation Deparment of Neurology, Universitatsklinikum Ulm, Ulm, Germany

  • Michael Danzer,

    Affiliation MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

  • Zhanyun Fan,

    Affiliation MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

  • Michael A. Schwarzschild,

    Affiliation MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

  • Warren Hirst,

    Affiliation Pfizer Neuroscience Research Unit, Cambridge, Massachusetts, United States of America

  • Pamela J. McLean

    nikolaus.mcfarland@neurology.ufl.edu (NRM); mclean.pamela@mayo.edu (PJM)

    Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

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