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Open Access

Peer-reviewed

Research Article

Tumor Mutation Burden Forecasts Outcome in Ovarian Cancer with BRCA1 or BRCA2 Mutations

  • Nicolai Juul Birkbak,

    Affiliations Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark

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  • Bose Kochupurakkal,

    Affiliation Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Jose M. G. Izarzugaza,

    Affiliation Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark

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  • Aron C. Eklund,

    Affiliation Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark

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  • Yang Li,

    Affiliation Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Joyce Liu,

    Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Zoltan Szallasi,

    Affiliations Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark, Children's Hospital Informatics Program at the Harvard-Massachusetts Institutes of Technology Division of Health Sciences and Technology (CHIP@HST), Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ursula A. Matulonis,

    Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Andrea L. Richardson,

    Affiliation Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

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  • J. Dirk Iglehart ,

    zhigang_wang@dfci.harvard.edu (ZCW); JIGLEHART@PARTNERS.ORG (JDI)

    Affiliations Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Surgery, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

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  • Zhigang C. Wang

    zhigang_wang@dfci.harvard.edu (ZCW); JIGLEHART@PARTNERS.ORG (JDI)

    Affiliations Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Surgery, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

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