Multiple Genetic Alterations within the PI3K Pathway Are Responsible for AKT Activation in Patients with Ovarian Carcinoma

Carmela De Marco; Nicola Rinaldo; Paola Bruni; Carmine Malzoni; Fulvio Zullo; Fernanda Fabiani; Simona Losito; Marianna Scrima; Federica Zito Marino; Renato Franco; Alfina Quintiero; Valter Agosti; Giuseppe Viglietto

doi:10.1371/journal.pone.0055362

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Open Access

Peer-reviewed

Research Article

Multiple Genetic Alterations within the PI3K Pathway Are Responsible for AKT Activation in Patients with Ovarian Carcinoma

Carmela De Marco,

Affiliations Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy, Biogem Scarl, Institute for Genetic Research “Gaetano Salvatore”, Ariano Irpino, Avellino, Italy
⨯
Nicola Rinaldo,

Affiliation Biogem Scarl, Institute for Genetic Research “Gaetano Salvatore”, Ariano Irpino, Avellino, Italy
⨯
Paola Bruni,

Affiliation Casa di Cura “Malzoni-Villa dei Platani”, Avellino, Italy
⨯
Carmine Malzoni,

Affiliation Casa di Cura “Malzoni-Villa dei Platani”, Avellino, Italy
⨯
Fulvio Zullo,

Affiliation Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy
⨯
Fernanda Fabiani,

Affiliation Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy
⨯
Simona Losito,

Affiliation Fondazione “G Pascale”, National Cancer Institute, Naples, Italy
⨯
Marianna Scrima,

Affiliations Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy, Biogem Scarl, Institute for Genetic Research “Gaetano Salvatore”, Ariano Irpino, Avellino, Italy
⨯
Federica Zito Marino,

Affiliation Fondazione “G Pascale”, National Cancer Institute, Naples, Italy
⨯
Renato Franco,

Affiliation Fondazione “G Pascale”, National Cancer Institute, Naples, Italy
⨯
Alfina Quintiero,

Affiliation Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy
⨯
Valter Agosti,

Affiliation Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy
⨯
Giuseppe Viglietto

* E-mail: viglietto@unicz.it

Affiliations Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy, Biogem Scarl, Institute for Genetic Research “Gaetano Salvatore”, Ariano Irpino, Avellino, Italy
⨯

Multiple Genetic Alterations within the PI3K Pathway Are Responsible for AKT Activation in Patients with Ovarian Carcinoma

Carmela De Marco,
Nicola Rinaldo,
Paola Bruni,
Carmine Malzoni,
Fulvio Zullo,
Fernanda Fabiani,
Simona Losito,
Marianna Scrima,
Federica Zito Marino,
Renato Franco

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Published: February 7, 2013
https://doi.org/10.1371/journal.pone.0055362

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Ovarian cancer
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Immunostaining
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Signal amplification
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Point mutation
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Cancers and neoplasms
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Fluorescent in situ hybridization
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Mutation detection
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Negative staining
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