High Expression of the Pi-Transporter SLC20A1/Pit1 in Calcific Aortic Valve Disease Promotes Mineralization through Regulation of Akt-1

Diala El Husseini; Marie-Chloé Boulanger; Dominique Fournier; Ablajan Mahmut; Yohan Bossé; Philippe Pibarot; Patrick Mathieu

doi:10.1371/journal.pone.0053393

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Research Article

High Expression of the Pi-Transporter SLC20A1/Pit1 in Calcific Aortic Valve Disease Promotes Mineralization through Regulation of Akt-1

Diala El Husseini,

Affiliation Laboratoire d’Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada
⨯
Marie-Chloé Boulanger,

Affiliation Laboratoire d’Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada
⨯
Dominique Fournier,

Affiliation Laboratoire d’Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada
⨯
Ablajan Mahmut,

Affiliation Laboratoire d’Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada
⨯
Yohan Bossé,

Affiliation Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, Canada
⨯
Philippe Pibarot,

Affiliation Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, Canada
⨯
Patrick Mathieu

* E-mail: patrick.mathieu@chg.ulaval.ca

Affiliation Laboratoire d’Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada
⨯

High Expression of the Pi-Transporter SLC20A1/Pit1 in Calcific Aortic Valve Disease Promotes Mineralization through Regulation of Akt-1

Diala El Husseini,
Marie-Chloé Boulanger,
Dominique Fournier,
Ablajan Mahmut,
Yohan Bossé,
Philippe Pibarot,
Patrick Mathieu

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Published: January 4, 2013
https://doi.org/10.1371/journal.pone.0053393

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Apoptosis
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Aortic valve
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Small interfering RNA
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Transfection
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Mitochondria
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Messenger RNA
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Calcification
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Mitochondrial membrane
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