Using Family-Based Imputation in Genome-Wide Association Studies with Large Complex Pedigrees: The Framingham Heart Study

• Ming-Huei Chen ,

  Contributed equally to this work with: Ming-Huei Chen, Jie Huang

  Affiliations Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, The National Heart, Lung, Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America

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• Jie Huang ,

  Contributed equally to this work with: Ming-Huei Chen, Jie Huang

  Affiliations The National Heart, Lung, Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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• Wei-Min Chen,

  Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

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• Martin G. Larson,

  Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, The National Heart, Lung, Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America, Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, United States of America

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• Caroline S. Fox,

  Affiliations The National Heart, Lung, Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America, Brigham and Women’s Hospital, Division of Endocrinology, Hypertension, and Diabetes and Harvard Medical School, Boston, Massachusetts, United States of America

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• Ramachandran S. Vasan,

  Affiliations The National Heart, Lung, Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America, Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, United States of America

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• Sudha Seshadri,

  Affiliations Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America, The National Heart, Lung, Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America

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• Christopher J. O’Donnell,

  Affiliations The National Heart, Lung, Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Qiong Yang

  * E-mail: qyang@bu.edu

  Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, The National Heart, Lung, Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America

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