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Cryptopleurine Analogs with Modification of E Ring Exhibit Different Mechanism to Rac-Cryptopleurine and Tylophorine

  • Ying Wang,

    Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

  • Hui-Chyn Wong,

    Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

  • Elizabeth A. Gullen,

    Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

  • Wing Lam,

    Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

  • Xiaoming Yang,

    Affiliation Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America

  • Qian Shi,

    Affiliation Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America

  • Kuo-Hsiung Lee ,

    yccheng@yale.edu (YCC); khlee@unc.edu (KHL)

    Affiliations Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America, Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan

  • Yung-Chi Cheng

    yccheng@yale.edu (YCC); khlee@unc.edu (KHL)

    Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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