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Open Access

Peer-reviewed

Research Article

Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice

  • Wendy W. J. Unger,

    Current address: Department of Molecular Cell Biology and Immunology, VUmc, Amsterdam, The Netherlands

    Affiliation Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

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  • Todd Pearson,

    Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Joana R. F. Abreu,

    Affiliation Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

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  • Sandra Laban,

    Affiliation Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

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  • Arno R. van der Slik,

    Affiliation Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

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  • Sacha Mulder-van der Kracht,

    Affiliation Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

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  • Michel G. D. Kester,

    Affiliation Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands

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  • Dave V. Serreze,

    Affiliation The Jackson Laboratory, Bar Harbor, Maine, United States of America

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  • Leonard D. Shultz,

    Affiliation The Jackson Laboratory, Bar Harbor, Maine, United States of America

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  • Marieke Griffioen,

    Affiliation Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands

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  • Jan Wouter Drijfhout,

    Affiliation Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

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  • Dale L. Greiner ,

    Contributed equally to this work with: Dale L. Greiner, Bart O. Roep

    Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Bart O. Roep

    Contributed equally to this work with: Dale L. Greiner, Bart O. Roep

    boroep@lumc.nl

    Affiliation Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

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