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Method for Evaluating Multiple Mediators: Mediating Effects of Smoking and COPD on the Association between the CHRNA5-A3 Variant and Lung Cancer Risk

  • Jian Wang,

    Affiliations Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

  • Margaret R. Spitz,

    Affiliation Department of Molecular and Cellular Biology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America

  • Christopher I. Amos,

    Affiliation Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

  • Xifeng Wu,

    Affiliation Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

  • David W. Wetter,

    Affiliation Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

  • Paul M. Cinciripini,

    Affiliation Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

  • Sanjay Shete

    sshete@mdanderson.org

    Affiliations Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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