Experimental and In Silico Modelling Analyses of the Gene Expression Pathway for Recombinant Antibody and By-Product Production in NS0 Cell Lines

Emma J. Mead; Lesley M. Chiverton; Sarah K. Spurgeon; Elaine B. Martin; Gary A. Montague; C. Mark Smales; Tobias von der Haar

doi:10.1371/journal.pone.0047422

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Open Access

Peer-reviewed

Research Article

Experimental and In Silico Modelling Analyses of the Gene Expression Pathway for Recombinant Antibody and By-Product Production in NS0 Cell Lines

Emma J. Mead ,

* E-mail: E.J.Mead@kent.ac.uk (EJM); C.M.Smales@kent.ac.uk (CMS); T.von-der-Haar@kent.ac.uk (TvdH)

Affiliations School of Biosciences, University of Kent, Canterbury, United Kingdom, Centre for Molecular Processing, University of Kent, Canterbury, United Kingdom
⨯
Lesley M. Chiverton,

Affiliations School of Biosciences, University of Kent, Canterbury, United Kingdom, Centre for Molecular Processing, University of Kent, Canterbury, United Kingdom
⨯
Sarah K. Spurgeon,

Affiliations School of Engineering and Digital Arts, University of Kent, Canterbury, United Kingdom, Centre for Molecular Processing, University of Kent, Canterbury, United Kingdom
⨯
Elaine B. Martin,

Affiliation School of Chemical Engineering and Advanced Materials, Newcastle University, Newcastle, United Kingdom
⨯
Gary A. Montague,

Affiliation School of Chemical Engineering and Advanced Materials, Newcastle University, Newcastle, United Kingdom
⨯
C. Mark Smales ,

* E-mail: E.J.Mead@kent.ac.uk (EJM); C.M.Smales@kent.ac.uk (CMS); T.von-der-Haar@kent.ac.uk (TvdH)

Affiliations School of Biosciences, University of Kent, Canterbury, United Kingdom, Centre for Molecular Processing, University of Kent, Canterbury, United Kingdom
⨯
Tobias von der Haar

* E-mail: E.J.Mead@kent.ac.uk (EJM); C.M.Smales@kent.ac.uk (CMS); T.von-der-Haar@kent.ac.uk (TvdH)

Affiliations School of Biosciences, University of Kent, Canterbury, United Kingdom, Centre for Molecular Processing, University of Kent, Canterbury, United Kingdom
⨯

Experimental and In Silico Modelling Analyses of the Gene Expression Pathway for Recombinant Antibody and By-Product Production in NS0 Cell Lines

Emma J. Mead,
Lesley M. Chiverton,
Sarah K. Spurgeon,
Elaine B. Martin,
Gary A. Montague,
C. Mark Smales,
Tobias von der Haar

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Published: October 10, 2012
https://doi.org/10.1371/journal.pone.0047422

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Secretion
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Gene expression
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Messenger RNA
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CHO cells
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Recombinant proteins
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Genetic engineering
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Polypeptides
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Monoclonal antibodies
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