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Open Access

Peer-reviewed

Research Article

Human Surfactant Protein A2 Gene Mutations Impair Dimmer/Trimer Assembly Leading to Deficiency in Protein Sialylation and Secretion

  • Yi Song ,

    Contributed equally to this work with: Yi Song, Guodong Fang

    Affiliation Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Guodong Fang ,

    Contributed equally to this work with: Yi Song, Guodong Fang

    Affiliation Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Haitao Shen,

    Affiliation Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Hui Li,

    Affiliation Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Wenbing Yang,

    Affiliation Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Bing Pan,

    Affiliation The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides of Health Ministry, Beijing, People’s Republic of China

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  • Guowei Huang,

    Affiliation Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Guangyu Lin,

    Affiliations Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China, Translational Medicine Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Lian Ma,

    Affiliations Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China, Translational Medicine Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Belinda Willard,

    Affiliation Proteomics Laboratory, Cleveland Clinic, Cleveland, Ohio, United States of America

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  • Jiang Gu,

    Affiliation Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Lemin Zheng ,

    yywangut@gmail.com (YW); zhengl@bjmu.edu.cn (LZ)

    Affiliation The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides of Health Ministry, Beijing, People’s Republic of China

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  • Yongyu Wang

    yywangut@gmail.com (YW); zhengl@bjmu.edu.cn (LZ)

    Affiliation Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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