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Hypothesis-Based Analysis of Gene-Gene Interactions and Risk of Myocardial Infarction

  • Gavin Lucas ,

    glucas@imim.es

    Affiliation Cardiovascular Epidemiology and Genetics, IMIM, Barcelona, Spain

  • Carla Lluís-Ganella,

    Affiliation Cardiovascular Epidemiology and Genetics, IMIM, Barcelona, Spain

  • Isaac Subirana,

    Affiliations Epidemiology and Public Health Network (CIBERESP), Barcelona, Spain, Cardiovascular Epidemiology and Genetics, IMIM, Barcelona, Spain

  • Muntaser D. Musameh,

    Affiliations Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom, Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom

  • Juan Ramon Gonzalez,

    Affiliations Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, Epidemiology and Public Health Network (CIBERESP), Barcelona, Spain, IMIM (Hospital del Mar Research Institute), Barcelona, Spain

  • Christopher P. Nelson,

    Affiliations Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom, Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom

  • Mariano Sentí,

    Affiliations Cardiovascular Epidemiology and Genetics, IMIM, Barcelona, Spain, Pompeu Fabra University, Barcelona, Spain

  • the Myocardial Infarction Genetics Consortium ,

    Contributed equally to this work with: the Myocardial Infarction Genetics Consortium, the Wellcome Trust Case Control Consortium

    Membership of the Myocardial Infarction Genetics Consortium and the Wellcome Trust Case Control Consortium is provided in File S1.

  • the Wellcome Trust Case Control Consortium ,

    Contributed equally to this work with: the Myocardial Infarction Genetics Consortium, the Wellcome Trust Case Control Consortium

    Membership of the Myocardial Infarction Genetics Consortium and the Wellcome Trust Case Control Consortium is provided in File S1.

  • Stephen M. Schwartz,

    Affiliation Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America

  • David Siscovick,

    Affiliation Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America

  • Christopher J. O’Donnell,

    Affiliations National, Heart, Lung, and Blood Institute and Framingham Heart Study, Framingham, Massachusetts, United States of America, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  • Olle Melander,

    Affiliation Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malmö, Lund University, Malmö, Sweden

  • Veikko Salomaa,

    Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

  • Shaun Purcell,

    Affiliations Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Stanley Center for Psychiatric Research, Broad Institute, Cambridge, Massachusetts, United States of America

  • David Altshuler,

    Affiliations The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  • Nilesh J. Samani,

    Affiliations Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom, Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom

  • Sekar Kathiresan,

    Affiliations Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  •  [ ... ],
  • Roberto Elosua

    Affiliations Cardiovascular Epidemiology and Genetics, IMIM, Barcelona, Spain, Epidemiology and Public Health Network (CIBERESP), Barcelona, Spain

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