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Twelve Positions in a β-Lactamase That Can Expand Its Substrate Spectrum with a Single Amino Acid Substitution

  • Hyojeong Yi,

    Affiliation Department of Medicine, College of Medicine, Korea University, Seoul, Korea

  • Kwang-Hwi Cho,

    Affiliation School of Systems Biomedical Science and Research Center for Integrative Basic Science, Soongsil University, Seoul, Korea

  • Yun Sung Cho,

    Affiliation School of Systems Biomedical Science and Research Center for Integrative Basic Science, Soongsil University, Seoul, Korea

  • Karan Kim,

    Affiliation Department of Medicine, College of Medicine, Korea University, Seoul, Korea

  • William C. Nierman,

    Affiliation J. Craig Venter Institute, Rockville, Maryland, United States of America

  • Heenam Stanley Kim

    hstanleykim@korea.ac.kr

    Affiliations Department of Medicine, College of Medicine, Korea University, Seoul, Korea, J. Craig Venter Institute, Rockville, Maryland, United States of America

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