Novel Quinazolinone MJ-29 Triggers Endoplasmic Reticulum Stress and Intrinsic Apoptosis in Murine Leukemia WEHI-3 Cells and Inhibits Leukemic Mice

• Chi-Cheng Lu,

  Affiliation Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan

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• Jai-Sing Yang,

  Affiliation Department of Pharmacology, China Medical University, Taichung, Taiwan

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• Jo-Hua Chiang,

  Affiliation Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan

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• Mann-Jen Hour,

  Affiliation School of Pharmacy, China Medical University, Taichung, Taiwan

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• Kuei-Li Lin,

  Affiliation Department of Radiation Oncology, Chi Mei Medical Center, Tainan, Taiwan

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• Jen-Jyh Lin,

  Affiliations Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan, Division of Cardiology, China Medical University Hospital, Taichung, Taiwan

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• Wen-Wen Huang,

  Affiliation Department of Biological Science and Technology, China Medical University, Taichung, Taiwan

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• Minoru Tsuzuki,

  Affiliations Department of Biochemistry, Nihon Pharmaceutical University, Saitama, Japan, Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung, Taiwan

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• Tsung-Han Lee ,

  Contributed equally to this work with: Tsung-Han Lee, Jing-Gung Chung

  * E-mail: jgchung@mail.cmu.edu.tw (JGC); thlee@dragon.nchu.edu.tw (THL)

  Affiliations Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan

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• Jing-Gung Chung

  Contributed equally to this work with: Tsung-Han Lee, Jing-Gung Chung

  * E-mail: jgchung@mail.cmu.edu.tw (JGC); thlee@dragon.nchu.edu.tw (THL)

  Affiliations Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, Department of Biotechnology, Asia University, Taichung, Taiwan

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