Assessment and Implication of Prognostic Imbalance in Randomized Controlled Trials with a Binary Outcome – A Simulation Study

• Rong Chu ,

  * E-mail: chur@mcmaster.ca

  Affiliation Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

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• Stephen D. Walter,

  Affiliation Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

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• Gordon Guyatt,

  Affiliation Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

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• P. J. Devereaux,

  Affiliations Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada, Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada

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• Michael Walsh,

  Affiliation Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

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• Kristian Thorlund,

  Affiliation Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

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• Lehana Thabane

  Affiliations Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada, Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada, Biostatistics Unit, Father Sean O'Sullivan Research Centre, St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada, The Centre for Evaluation of Medicines, St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada

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