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Research Article

Designing and Analyzing Clinical Trials with Composite Outcomes: Consideration of Possible Treatment Differences between the Individual Outcomes

  • Janice Pogue equal contributor mail,

    equal contributor Contributed equally to this work with: Janice Pogue, P. J. Devereaux, Lehana Thabane, Salim Yusuf

    janice.pogue@phri.ca

    Affiliations: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

    X
  • P. J. Devereaux equal contributor,

    equal contributor Contributed equally to this work with: Janice Pogue, P. J. Devereaux, Lehana Thabane, Salim Yusuf

    Affiliations: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

    X
  • Lehana Thabane equal contributor,

    equal contributor Contributed equally to this work with: Janice Pogue, P. J. Devereaux, Lehana Thabane, Salim Yusuf

    Affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada

    X
  • Salim Yusuf equal contributor

    equal contributor Contributed equally to this work with: Janice Pogue, P. J. Devereaux, Lehana Thabane, Salim Yusuf

    Affiliations: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

    X
  • Published: April 17, 2012
  • DOI: 10.1371/journal.pone.0034785

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