Chronic Immune Activation in HIV-1 Infection Contributes to Reduced Interferon Alpha Production via Enhanced CD40:CD40 Ligand Interaction

• Norbert Donhauser,

  Affiliation Institute of Clinical and Molecular Virology, German National Reference Centre for Retroviruses, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

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• Kathrin Pritschet,

  Affiliation Institute of Clinical and Molecular Virology, German National Reference Centre for Retroviruses, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

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• Martin Helm,

  Affiliation Praxis Dr. G. Abelein/Dr. M. Helm, Nürnberg, Germany

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• Thomas Harrer,

  Affiliation Department for Internal Medicine III, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

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• Philipp Schuster,

  Affiliation Institute of Clinical and Molecular Virology, German National Reference Centre for Retroviruses, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

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• Moritz Ries,

  Affiliation Institute of Clinical and Molecular Virology, German National Reference Centre for Retroviruses, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

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• Georg Bischof,

  Affiliation Institute of Clinical and Molecular Virology, German National Reference Centre for Retroviruses, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

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• Jörg Vollmer,

  Affiliation Pfizer Oligonucleotide Therapeutics Unit, Coley Pharmaceutical GmbH, Düsseldorf, Germany

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• Sigrun Smola,

  Affiliation Institute of Virology, Saarland University, Homburg/Saar, Germany

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• Barbara Schmidt ,

  * E-mail: baschmid@viro.med.uni-erlangen.de

  Affiliation Institute of Clinical and Molecular Virology, German National Reference Centre for Retroviruses, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

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• for the German Competence Network HIV/AIDS