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Open Access

Peer-reviewed

Research Article

A Whole Cell Assay to Measure Caspase-6 Activity by Detecting Cleavage of Lamin A/C

  • Robert Mintzer,

    Affiliation Department of Biochemical Pharmacology, Genentech, Inc., South San Francisco, California, United States of America

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  • Sreemathy Ramaswamy,

    Affiliation Department of Biochemical Pharmacology, Genentech, Inc., South San Francisco, California, United States of America

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  • Kinjalkumar Shah,

    Affiliation Department of Biochemical Pharmacology, Genentech, Inc., South San Francisco, California, United States of America

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  • Rami N. Hannoush,

    Affiliation Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, California, United States of America

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  • Christine D. Pozniak,

    Affiliation Department of Neuroscience, Genentech, Inc., South San Francisco, California, United States of America

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  • Frederick Cohen,

    Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America

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  • Xianrui Zhao,

    Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America

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  • Emile Plise,

    Affiliation Department of Drug Metabolism and PK, Genentech, Inc., South San Francisco, California, United States of America

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  • Joseph W. Lewcock,

    Affiliation Department of Neuroscience, Genentech, Inc., South San Francisco, California, United States of America

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  • Christopher E. Heise

    heise.christopher@gene.com

    Affiliation Department of Biochemical Pharmacology, Genentech, Inc., South San Francisco, California, United States of America

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