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Open Access

Peer-reviewed

Research Article

Testosterone Deficiency Accelerates Neuronal and Vascular Aging of SAMP8 Mice: Protective Role of eNOS and SIRT1

  • Hidetaka Ota,

    Affiliation Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan

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  • Masahiro Akishita ,

    akishita-tky@umin.ac.jp

    Affiliation Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan

    ⨯
  • Takuyu Akiyoshi,

    Affiliation Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan

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  • Tomoaki Kahyo,

    Affiliation Hamamatsu University School of Medicine, Department of Molecular Anatomy, Hamamatsu, Shizuoka, Japan

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  • Mitsutoshi Setou,

    Affiliation Hamamatsu University School of Medicine, Department of Molecular Anatomy, Hamamatsu, Shizuoka, Japan

    ⨯
  • Sumito Ogawa,

    Affiliation Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan

    ⨯
  • Katsuya Iijima,

    Affiliation Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan

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  • Masato Eto,

    Affiliation Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan

    ⨯
  • Yasuyoshi Ouchi

    Affiliation Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan

    ⨯

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