Genetic Profiling Using Genome-Wide Significant Coronary Artery Disease Risk Variants Does Not Improve the Prediction of Subclinical Atherosclerosis: The Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey – A Meta-Analysis of Three Independent Studies

• Jussi A. Hernesniemi ,

  Contributed equally to this work with: Jussi A. Hernesniemi, Ilkka Seppälä

  * E-mail: jussi.hernesniemi@uta.fi

  Affiliation Department of Clinical Chemistry, University of Tampere, Medical School, and Tampere University Hospital, Tampere, Finland

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• Ilkka Seppälä ,

  Contributed equally to this work with: Jussi A. Hernesniemi, Ilkka Seppälä

  Affiliation Department of Clinical Chemistry, University of Tampere, Medical School, and Tampere University Hospital, Tampere, Finland

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• Leo-Pekka Lyytikäinen,

  Affiliation Department of Clinical Chemistry, University of Tampere, Medical School, and Tampere University Hospital, Tampere, Finland

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• Nina Mononen,

  Affiliation Department of Clinical Chemistry, University of Tampere, Medical School, and Tampere University Hospital, Tampere, Finland

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• Niku Oksala,

  Affiliations Department of Clinical Chemistry, University of Tampere, Medical School, and Tampere University Hospital, Tampere, Finland, Department of Surgery, University of Tampere, Medical School, and Tampere University Hospital, Tampere, Finland

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• Nina Hutri-Kähönen,

  Affiliation Department of Pediatrics, University of Tampere, Medical School, and Tampere University Hospital, Tampere, Finland

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• Markus Juonala,

  Affiliations Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland

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• Leena Taittonen,

  Affiliation Department of Pediatrics, University of Oulu and Oulu University Hospital, Oulu, Finland and Department of Pediatrics, Vaasa Central Hospital, Vaasa, Finland

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• Erin N. Smith,

  Affiliation The Scripps Translational Science Institute and Scripps Health, La Jolla, California, United States of America

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• Nicholas J. Schork,

  Affiliations The Scripps Translational Science Institute and Scripps Health, La Jolla, California, United States of America, The Scripps Research Institute, La Jolla, California, United States of America

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• Wei Chen,

  Affiliation Department of Epidemiology, Tulane University, New Orleans, Louisiana, United States of America

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• Sathanur R. Srinivasan,

  Affiliation Department of Epidemiology, Tulane University, New Orleans, Louisiana, United States of America

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• Gerald S. Berenson,

  Affiliation Department of Epidemiology, Tulane University, New Orleans, Louisiana, United States of America

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• Sarah S. Murray,

  Affiliations The Scripps Translational Science Institute and Scripps Health, La Jolla, California, United States of America, The Scripps Research Institute, La Jolla, California, United States of America

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• Tomi Laitinen,

  Affiliation Department of Clinical Physiology and Nuclear Medicine, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland

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• Antti Jula,

  Affiliation Department of Health and Functional Capacity, National Public Health Institute, Turku, Finland

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• Johannes Kettunen,

  Affiliation FIMM, Institute for Molecular Medicine Finland, Helsinki, Finland

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• Samuli Ripatti,

  Affiliation FIMM, Institute for Molecular Medicine Finland, Helsinki, Finland

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• Reijo Laaksonen,

  Affiliation Department of Clinical Chemistry, University of Tampere, Medical School, and Tampere University Hospital, Tampere, Finland

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• Jorma Viikari,

  Affiliation Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland

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• Mika Kähönen,

  Affiliation Department of Clinical Physiology, University of Tampere, Medical School, and Tampere University Hospital, Tampere, Finland

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• Olli T. Raitakari,

  Affiliations Department of Clinical Physiology, University of Turku and Turku University Hospital, Turku, Finland, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland

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•  [ ... ],
• Terho Lehtimäki

  Affiliation Department of Clinical Chemistry, University of Tampere, Medical School, and Tampere University Hospital, Tampere, Finland

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