Cooperative Genome-Wide Analysis Shows Increased Homozygosity in Early Onset Parkinson's Disease

• Javier Simón-Sánchez ,

  Contributed equally to this work with: Javier Simón-Sánchez, Laura L. Kilarski

  Affiliation Section of Medical Genomics, Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands

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• Laura L. Kilarski ,

  Contributed equally to this work with: Javier Simón-Sánchez, Laura L. Kilarski

  Affiliations MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom, Department of Psychological Medicine & Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom

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• Michael A. Nalls,

  Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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• Maria Martinez,

  Affiliations Inserm, UMR 1043, Toulouse, France, Paul Sabatier University, Toulouse, France

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• Claudia Schulte,

  Affiliation Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, and DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany

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• Peter Holmans,

  Affiliations MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom, Department of Psychological Medicine & Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom

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• International Parkinson's Disease Genomics Consortium ,

  ¶a Membership of the International Parkinson's Disease Genomics Consortium is provided in the Acknowledgments.

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• Wellcome Trust Case Control Consortium ,

  ¶b Membership of the Wellcome Trust Case Control Consortium is provided in supporting information.

  Affiliation MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom

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• Thomas Gasser,

  Affiliation Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, and DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany

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• John Hardy,

  Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom

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• Andrew B. Singleton,

  Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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• Nicholas W. Wood,

  Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom

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• Alexis Brice,

  Affiliations Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France, Inserm, U975, Paris, France, Cnrs, UMR 7225, Paris, France

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• Peter Heutink,

  Affiliation Section of Medical Genomics, Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands

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• Nigel Williams ,

  * E-mail: williamsnm@cf.ac.uk (NW); morrishr@cf.ac.uk (HRM)

  Affiliations MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom, Department of Psychological Medicine & Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom

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•  [ ... ],
• Huw R. Morris

  * E-mail: williamsnm@cf.ac.uk (NW); morrishr@cf.ac.uk (HRM)

  Affiliations MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom, Department of Psychological Medicine & Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom

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