An RGS4-Mediated Phenotypic Switch of Bronchial Smooth Muscle Cells Promotes Fixed Airway Obstruction in Asthma

• Gautam Damera,

  Affiliation Airways Biology Initiative, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Kirk M. Druey,

  Affiliation National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Philip R. Cooper,

  Affiliation Airways Biology Initiative, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Vera P. Krymskaya,

  Affiliation Airways Biology Initiative, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Roy J. Soberman,

  Affiliation Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Yassine Amrani,

  Affiliation University of Leicester, Leicester, United Kingdom

  ⨯
• Toshinori Hoshi,

  Affiliation Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Christopher E. Brightling,

  Affiliation University of Leicester, Leicester, United Kingdom

  ⨯
• Reynold A. Panettieri Jr

  * E-mail: rap@mail.med.upenn.edu

  Affiliation Airways Biology Initiative, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯