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Research Article

Caloric Restriction Alters the Metabolic Response to a Mixed-Meal: Results from a Randomized, Controlled Trial

  • Kim M. Huffman mail,

    huffm007@mc.duke.edu

    Affiliations: Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, North Carolina, United States of America, Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, Center for Aging and Human Development, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Leanne M. Redman,

    Affiliation: Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

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  • Lawrence R. Landerman,

    Affiliation: Center for Aging and Human Development, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Carl F. Pieper,

    Affiliation: Center for Aging and Human Development, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Robert D. Stevens,

    Affiliation: Sarah W. Stedman Nutrition and Metabolism Center and Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Michael J. Muehlbauer,

    Affiliation: Sarah W. Stedman Nutrition and Metabolism Center and Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Brett R. Wenner,

    Affiliation: Sarah W. Stedman Nutrition and Metabolism Center and Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • James R. Bain,

    Affiliation: Sarah W. Stedman Nutrition and Metabolism Center and Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Virginia B. Kraus,

    Affiliations: Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, Center for Aging and Human Development, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Christopher B. Newgard,

    Affiliation: Sarah W. Stedman Nutrition and Metabolism Center and Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Eric Ravussin,

    Affiliation: Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

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  • William E. Kraus

    Affiliations: Center for Aging and Human Development, Duke University Medical Center, Durham, North Carolina, United States of America, Sarah W. Stedman Nutrition and Metabolism Center and Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, Division of Cardiovascular Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Published: April 16, 2012
  • DOI: 10.1371/journal.pone.0028190

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