In Vitro Effects of Pirfenidone on Cardiac Fibroblasts: Proliferation, Myofibroblast Differentiation, Migration and Cytokine Secretion

Qiang Shi; Xiaoyan Liu; Yuanyuan Bai; Chuanjue Cui; Jun Li; Yishi Li; Shengshou Hu; Yingjie Wei

doi:10.1371/journal.pone.0028134

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Peer-reviewed

Research Article

In Vitro Effects of Pirfenidone on Cardiac Fibroblasts: Proliferation, Myofibroblast Differentiation, Migration and Cytokine Secretion

Qiang Shi,

Affiliation State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People Republic China
⨯
Xiaoyan Liu,

Affiliation State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People Republic China
⨯
Yuanyuan Bai,

Affiliation State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People Republic China
⨯
Chuanjue Cui,

Affiliation State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People Republic China
⨯
Jun Li,

Affiliation State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People Republic China
⨯
Yishi Li,

Affiliation State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People Republic China
⨯
Shengshou Hu ,

* E-mail: weiyingjiefw@126.com (YW); shengshouhu@yahoo.com (SH)

Affiliation State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People Republic China
⨯
Yingjie Wei

* E-mail: weiyingjiefw@126.com (YW); shengshouhu@yahoo.com (SH)

Affiliation State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People Republic China
⨯

In Vitro Effects of Pirfenidone on Cardiac Fibroblasts: Proliferation, Myofibroblast Differentiation, Migration and Cytokine Secretion

Qiang Shi,
Xiaoyan Liu,
Yuanyuan Bai,
Chuanjue Cui,
Jun Li,
Yishi Li,
Shengshou Hu,
Yingjie Wei

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Published: November 23, 2011
https://doi.org/10.1371/journal.pone.0028134

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Fibroblasts
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Secretion
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Fibrosis
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Protein secretion
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