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Open Access

Peer-reviewed

Research Article

Streamlining Homogeneous Glycoprotein Production for Biophysical and Structural Applications by Targeted Cell Line Development

  • Sonja Wilke,

    Affiliation Department of Molecular Structural Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Lothar Groebe,

    Affiliation Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Vitali Maffenbeier,

    Affiliation Department of Molecular Structural Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Volker Jäger,

    Affiliation Department of Molecular Structural Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Manfred Gossen,

    Affiliations Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany, Berlin-Brandenburg Centre for Regenerative Therapies (BCRT), Berlin, Germany

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  • Jörn Josewski,

    Affiliation Department of Molecular Structural Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Agathe Duda,

    Affiliation Department of Molecular Structural Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Lilia Polle,

    Affiliation Department of Molecular Structural Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Raymond J. Owens,

    Affiliations Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Oxford, United Kingdom, Oxford Protein Production Facility UK, The Research Complex at Harwell, Rutherford Appleton Laboratory Harwell Science and Innovation Campus, Oxfordshire, United Kingdom

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  • Dagmar Wirth,

    Affiliation Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Dirk W. Heinz,

    Affiliation Department of Molecular Structural Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Joop van den Heuvel,

    Affiliation Department of Molecular Structural Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Konrad Büssow

    konrad.buessow@helmholtz-hzi.de

    Affiliation Department of Molecular Structural Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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