Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model

• María B. Cassera,

  Current address: Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United State of America

  Affiliation Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, United State of America

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• Keith Z. Hazleton,

  Affiliation Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, United State of America

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• Emilio F. Merino,

  Current address: Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United State of America

  Affiliation Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, United State of America

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• Nicanor Obaldia III,

  Affiliation Tropical Medicine Research, Malaria Drug and Vaccine Evaluation Center, Gorgas Memorial Institute of Health Studies, Panama City, Panama

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• Meng-Chiao Ho,

  Affiliation Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, United State of America

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• Andrew S. Murkin,

  Affiliations Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, United State of America, Department of Chemistry, University at Buffalo, Buffalo, New York, United State of America

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• Richard DePinto,

  Affiliation Waters Corporation, Parsippany, New Jersey, United State of America

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• Jemy A. Gutierrez,

  Affiliation Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, United State of America

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• Steven C. Almo,

  Affiliation Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, United State of America

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• Gary B. Evans,

  Affiliation Carbohydrate Chemistry Group, Industrial Research Ltd., Lower Hutt, New Zealand

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• Yarlagadda S. Babu,

  Affiliation Department of Biological Sciences, BioCryst Pharmaceuticals Inc., Birmingham, Alabama, United State of America

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• Vern L. Schramm

  * E-mail: vern.schramm@einstein.yu.edu

  Affiliation Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, United State of America

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