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Methylation of the CpG Sites Only on the Sense Strand of the APC Gene Is Specific for Hepatocellular Carcinoma

  • Surbhi Jain,

    Affiliation Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

  • Ting-Tsung Chang ,

    Contributed equally to this work with: Ting-Tsung Chang, James P. Hamilton

    Affiliation Department of Medicine, Infectious Diseases and Signaling Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China

  • James P. Hamilton ,

    Contributed equally to this work with: Ting-Tsung Chang, James P. Hamilton

    Affiliation Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  • Selena Y. Lin,

    Affiliation Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

  • Yih-Jyh Lin,

    Affiliation Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China

  • Alison A. Evans,

    Affiliation School of Public Health, Drexel University, Philadelphia, Pennsylvania, United States of America

  • Florin M. Selaru,

    Affiliation Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  • Pin- Wen Lin,

    Affiliation Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China

  • Shun-Hua Chen,

    Affiliation Department of Microbiology, Medical College, National Cheng Kung University, Tainan, Taiwan, Republic of China

  • Timothy M. Block,

    Affiliation Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

  • Chi-Tan Hu,

    Affiliation Department of General Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, Republic of China

  • Wei Song,

    Affiliation JBS Science Inc., Philadelphia, Pennsylvania, United States of America

  • Stephen J. Meltzer,

    Affiliations Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, United States of America

  • Ying-Hsiu Su

    Ying-hsiu.Su@drexelmed.edu

    Affiliation Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

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