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The Number of Patients and Events Required to Limit the Risk of Overestimation of Intervention Effects in Meta-Analysis—A Simulation Study

  • Kristian Thorlund ,

    thorluk@mcmaster.ca

    Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

  • Georgina Imberger,

    Affiliation Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

  • Michael Walsh,

    Affiliation Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada

  • Rong Chu,

    Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada, Biostatistics Unit, Father Sean O'Sullivan Research Centre, St Joseph's Healthcare Hamilton, Hamilton, Canada

  • Christian Gluud,

    Affiliation Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

  • Jørn Wetterslev,

    Affiliation Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

  • Gordon Guyatt,

    Affiliation Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada

  • Philip J. Devereaux,

    Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada, Public Health Research Institute, McMaster University, Hamilton, Canada

  • Lehana Thabane

    Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada, Biostatistics Unit, Father Sean O'Sullivan Research Centre, St Joseph's Healthcare Hamilton, Hamilton, Canada

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