Evolution of a Major Drug Metabolizing Enzyme Defect in the Domestic Cat and Other Felidae: Phylogenetic Timing and the Role of Hypercarnivory

• Binu Shrestha,

  Affiliations Comparative and Molecular Pharmacogenomics Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Department of Biology, Tufts University, Medford, Massachusetts, United States of America

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• J. Michael Reed,

  Affiliation Department of Biology, Tufts University, Medford, Massachusetts, United States of America

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• Philip T. Starks,

  Affiliation Department of Biology, Tufts University, Medford, Massachusetts, United States of America

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• Gretchen E. Kaufman,

  Affiliation Department of Environmental and Population Health, Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America

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• Jared V. Goldstone,

  Affiliation Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, United States of America

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• Melody E. Roelke,

  Affiliation Laboratory of Genomic Diversity, SAIC-Frederick Incorporated, National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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• Stephen J. O'Brien,

  Affiliation Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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• Klaus-Peter Koepfli,

  Affiliation Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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• Laurence G. Frank,

  Affiliation Living with Lions Project (Kenya), Museum of Vertebrate Zoology, University of California, Berkeley, California, United States of America

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• Michael H. Court

  * E-mail: michael.court@tufts.edu

  Affiliation Comparative and Molecular Pharmacogenomics Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America

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