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BRAF V600E Mutations Are Common in Pleomorphic Xanthoastrocytoma: Diagnostic and Therapeutic Implications

  • Dora Dias-Santagata,

    Affiliation Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  • Quynh Lam,

    Affiliation Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  • Kathy Vernovsky,

    Affiliation Division of Hematology-Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts, United States of America

  • Natalie Vena,

    Affiliations Department of Medical Oncology, Dana–Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for Molecular Oncologic Pathology, Dana–Farber Cancer Institute, Boston, Massachusetts, United States of America

  • Jochen K. Lennerz,

    Affiliation Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  • Darrell R. Borger,

    Affiliation Division of Hematology-Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts, United States of America

  • Tracy T. Batchelor,

    Affiliations Division of Hematology-Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Neurology and Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  • Keith L. Ligon,

    Affiliations Department of Medical Oncology, Dana–Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for Molecular Oncologic Pathology, Dana–Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  • A. John Iafrate,

    Affiliation Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  • Azra H. Ligon,

    Affiliations Center for Molecular Oncologic Pathology, Dana–Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  • David N. Louis,

    Affiliation Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  • Sandro Santagata

    ssantagata@partners.org

    Affiliations Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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