Genome-Wide Analysis of Transcriptional Reprogramming in Mouse Models of Acute Myeloid Leukaemia

Nicolas Bonadies; Samuel D. Foster; Wai-In Chan; Brynn T. Kvinlaug; Dominik Spensberger; Mark A. Dawson; Elaine Spooncer; Anthony D. Whetton; Andrew J. Bannister; Brian J. Huntly; Berthold Göttgens

doi:10.1371/journal.pone.0016330

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Open Access

Peer-reviewed

Research Article

Genome-Wide Analysis of Transcriptional Reprogramming in Mouse Models of Acute Myeloid Leukaemia

Nicolas Bonadies,

Affiliation Department of Haematology, Cambridge Institute for Medical Research, Cambridge University, Cambridge, United Kingdom
⨯
Samuel D. Foster,

Affiliation Department of Haematology, Cambridge Institute for Medical Research, Cambridge University, Cambridge, United Kingdom
⨯
Wai-In Chan,

Affiliation Department of Haematology, Cambridge Institute for Medical Research, Cambridge University, Cambridge, United Kingdom
⨯
Brynn T. Kvinlaug,

Affiliation Department of Haematology, Cambridge Institute for Medical Research, Cambridge University, Cambridge, United Kingdom
⨯
Dominik Spensberger,

Affiliation Department of Haematology, Cambridge Institute for Medical Research, Cambridge University, Cambridge, United Kingdom
⨯
Mark A. Dawson,

Affiliation Department of Haematology, Cambridge Institute for Medical Research, Cambridge University, Cambridge, United Kingdom
⨯
Elaine Spooncer,

Affiliation School of Cancer and Imaging Sciences, University of Manchester, Manchester, United Kingdom
⨯
Anthony D. Whetton,

Affiliation School of Cancer and Imaging Sciences, University of Manchester, Manchester, United Kingdom
⨯
Andrew J. Bannister,

Affiliation Gurdon Institute and Department of Pathology, Cambridge University, Cambridge, United Kingdom
⨯
Brian J. Huntly,

Affiliation Department of Haematology, Cambridge Institute for Medical Research, Cambridge University, Cambridge, United Kingdom
⨯
Berthold Göttgens

* E-mail: bg200@cam.ac.uk

Affiliation Department of Haematology, Cambridge Institute for Medical Research, Cambridge University, Cambridge, United Kingdom
⨯

Genome-Wide Analysis of Transcriptional Reprogramming in Mouse Models of Acute Myeloid Leukaemia

Nicolas Bonadies,
Samuel D. Foster,
Wai-In Chan,
Brynn T. Kvinlaug,
Dominik Spensberger,
Mark A. Dawson,
Elaine Spooncer,
Anthony D. Whetton,
Andrew J. Bannister,
Brian J. Huntly

x

Published: January 28, 2011
https://doi.org/10.1371/journal.pone.0016330

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Leukemia
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Transcriptional control
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Mouse models
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Gene expression
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Histone acetylation
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Transcription factors
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Cell differentiation
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DNA transcription
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