Epigenetic-Genetic Chromosome Dosage Approach for Fetal Trisomy 21 Detection Using an Autosomal Genetic Reference Marker

Yu K. Tong; Rossa W. K. Chiu; Ranjit Akolekar; Tak Y. Leung; Tze K. Lau; Kypros H. Nicolaides; Y. M. Dennis Lo

doi:10.1371/journal.pone.0015244

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Peer-reviewed

Research Article

Epigenetic-Genetic Chromosome Dosage Approach for Fetal Trisomy 21 Detection Using an Autosomal Genetic Reference Marker

Yu K. Tong,

Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China
⨯
Rossa W. K. Chiu,

Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China
⨯
Ranjit Akolekar,

Affiliation Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, United Kingdom
⨯
Tak Y. Leung,

Affiliation Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China
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Tze K. Lau,

Affiliation Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China
⨯
Kypros H. Nicolaides,

Affiliation Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, United Kingdom
⨯
Y. M. Dennis Lo

* E-mail: loym@cuhk.edu.hk

Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China
⨯

Epigenetic-Genetic Chromosome Dosage Approach for Fetal Trisomy 21 Detection Using an Autosomal Genetic Reference Marker

Yu K. Tong,
Rossa W. K. Chiu,
Ranjit Akolekar,
Tak Y. Leung,
Tze K. Lau,
Kypros H. Nicolaides,
Y. M. Dennis Lo

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Published: December 20, 2010
https://doi.org/10.1371/journal.pone.0015244

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Single nucleotide polymorphisms
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Polymerase chain reaction
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Pregnancy
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Homozygosity
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Genetic loci
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Alleles
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DNA methylation
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Fetuses
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