Fiber Type Conversion by PGC-1α Activates Lysosomal and Autophagosomal Biogenesis in Both Unaffected and Pompe Skeletal Muscle

Shoichi Takikita; Cynthia Schreiner; Rebecca Baum; Tao Xie; Evelyn Ralston; Paul H. Plotz; Nina Raben

doi:10.1371/journal.pone.0015239

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Peer-reviewed

Research Article

Fiber Type Conversion by PGC-1α Activates Lysosomal and Autophagosomal Biogenesis in Both Unaffected and Pompe Skeletal Muscle

Shoichi Takikita,

Affiliation Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Cynthia Schreiner,

Affiliation Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Rebecca Baum,

Affiliation Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Tao Xie,

Affiliation Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Evelyn Ralston,

Affiliation Light Imaging Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Paul H. Plotz,

Affiliation Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Nina Raben

* E-mail: rabenn@mail.nih.gov

Affiliation Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Fiber Type Conversion by PGC-1α Activates Lysosomal and Autophagosomal Biogenesis in Both Unaffected and Pompe Skeletal Muscle

Shoichi Takikita,
Cynthia Schreiner,
Rebecca Baum,
Tao Xie,
Evelyn Ralston,
Paul H. Plotz,
Nina Raben

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Published: December 13, 2010
https://doi.org/10.1371/journal.pone.0015239

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Skeletal muscles
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Glycogens
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Lysosomes
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Fast-twitch muscle fibers
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Muscle proteins
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Genetically modified animals
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Slow-twitch muscle fibers
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Gastrocnemius muscles
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