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PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

  • Jun Wei,

    Affiliation Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

  • Asish K. Ghosh,

    Current address: Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, Illinois, United States of America.

    Affiliation Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

  • Jennifer L. Sargent,

    Affiliation Department of Genetics, Dartmouth Medical College, Hanover, New Hampshire, United States of America

  • Kazuhiro Komura,

    Affiliation Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

  • Minghua Wu,

    Affiliation Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

  • Qi-Quan Huang,

    Affiliation Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

  • Manu Jain,

    Affiliation Division of Respiratory and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

  • Michael L. Whitfield,

    Affiliation Department of Genetics, Dartmouth Medical College, Hanover, New Hampshire, United States of America

  • Carol Feghali-Bostwick,

    Affiliation Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

  • John Varga

    j-varga@northwestern.edu

    Affiliation Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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