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Open Access

Peer-reviewed

Research Article

DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A

  • Lotte Coelmont,

    Affiliation Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium

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  • Xavier Hanoulle,

    Affiliation Centre National de Recherche Scientifique – Unité Mixte de Recherche 8576, Université de Lille 1, Villeneuve d'Ascq, France

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  • Udayan Chatterji,

    Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Carola Berger,

    Affiliation Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Joke Snoeck,

    Affiliation Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium

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  • Michael Bobardt,

    Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Precious Lim,

    Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Inge Vliegen,

    Affiliation Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium

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  • Jan Paeshuyse,

    Affiliation Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium

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  • Grégoire Vuagniaux,

    Affiliation Pharmacology and Screening Unit, Debiopharm, Lausanne, Switzerland

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  • Anne-Mieke Vandamme,

    Affiliation Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium

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  • Ralf Bartenschlager,

    Affiliation Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Philippe Gallay,

    Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Guy Lippens,

    Affiliation Centre National de Recherche Scientifique – Unité Mixte de Recherche 8576, Université de Lille 1, Villeneuve d'Ascq, France

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  • Johan Neyts

    johan.neyts@rega.kuleuven.be

    Affiliation Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium

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