The rs10993994 Risk Allele for Prostate Cancer Results in Clinically Relevant Changes in Microseminoprotein-Beta Expression in Tissue and Urine

• Hayley C. Whitaker ,

  * E-mail: Hayley.Whitaker@cancer.org.uk

  Affiliation Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom

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• Zsofia Kote-Jarai ,

  Contributed equally to this work with: Zsofia Kote-Jarai, Helen Ross-Adams

  Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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• Helen Ross-Adams ,

  Contributed equally to this work with: Zsofia Kote-Jarai, Helen Ross-Adams

  Affiliation Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom

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• Anne Y. Warren,

  Affiliation Department of Pathology, Addenbrookes Hospital, Cambridge, United Kingdom

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• Johanna Burge,

  Affiliation Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom

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• Anne George,

  Affiliation Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom

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• Elizabeth Bancroft,

  Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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• Sameer Jhavar,

  Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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• Daniel Leongamornlert,

  Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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• Malgorzata Tymrakiewicz,

  Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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• Edward Saunders,

  Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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• Elizabeth Page,

  Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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• Anita Mitra,

  Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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• Gillian Mitchell,

  Affiliation Peter Maccallum Cancer Centre, Victoria, Australia

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• Geoffrey J. Lindeman,

  Affiliation The Royal Melbourne Hospital and The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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• D. Gareth Evans,

  Affiliation Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom

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• Ignacio Blanco,

  Affiliation Catalonian Institute of Oncology, L'Hospitalet, Barcelona, Spain

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• Catherine Mercer,

  Affiliation Wessex Clinical Genetics Service, The Princess Anne Hospital, Southampton, United Kingdom

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• Wendy S. Rubinstein,

  Affiliation NorthShore University Health System, Evanston, Illinois, United States of America

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• Virginia Clowes,

  Affiliation Department of Clinical Genetics, Addenbrookes Hospital, Cambridge, United Kingdom

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• Fiona Douglas,

  Affiliation Institute of Human Genetics, Newcastle-Upon-Tyne, United Kingdom

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• Shirley Hodgson,

  Affiliation St George's, University of London, London, United Kingdom

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• Lisa Walker,

  Affiliation Oxford Regional Genetics Centre, Churchill Hospital, Oxford, United Kingdom

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• Alan Donaldson,

  Affiliation St Michael's Hospital, Bristol, United Kingdom

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• Louise Izatt,

  Affiliation Guy's Hospital, London, United Kingdom

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• Huw Dorkins,

  Affiliation Kennedy Galton Centre, Northwick Park Hospital, Harrow, Middlesex, United Kingdom

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• Alison Male,

  Affiliation Institute of Child Health, London, United Kingdom

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• Kathy Tucker,

  Affiliation Prince of Wales Hospital, Sydney, New South Wales, Australia

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• Alan Stapleton,

  Affiliation Repatriation General Hospital, Adelaide, Australia

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• Jimmy Lam,

  Affiliation Repatriation General Hospital, Adelaide, Australia

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• Judy Kirk,

  Affiliation Familial Cancer Service, Westmead Hospital, Westmead, New South Wales, Australia

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• Hans Lilja,

  Affiliation Departments of Clinical Laboratories, Surgery, Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Douglas Easton,

  Affiliation Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

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• The IMPACT Study Steering Committee ,

  ¶List of The IMPACT Study Steering Committee available on request.

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• The IMPACT Study Collaborators ,

  ¶List of The IMPACT Study Collaborators available on request.

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• UK GPCS Collaborators ,

  ¶List of UK GPCS Collaborators available on request.

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• Colin Cooper,

  Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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• Rosalind Eeles,

  Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

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•  [ ... ],
• David E. Neal

  Affiliation Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom

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