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Open Access

Peer-reviewed

Research Article

Ketogenic Essential Amino Acids Modulate Lipid Synthetic Pathways and Prevent Hepatic Steatosis in Mice

  • Yasushi Noguchi ,

    Contributed equally to this work with: Yasushi Noguchi, Natsumi Nishikata, Nahoko Shikata

    Affiliations Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Research Institute for Health Fundamentals, Ajinomoto Co. Inc., Kawasaki, Kanagawa, Japan

    ⨯
  • Natsumi Nishikata ,

    Contributed equally to this work with: Yasushi Noguchi, Natsumi Nishikata, Nahoko Shikata

    Affiliation Research Institute for Health Fundamentals, Ajinomoto Co. Inc., Kawasaki, Kanagawa, Japan

    ⨯
  • Nahoko Shikata ,

    Contributed equally to this work with: Yasushi Noguchi, Natsumi Nishikata, Nahoko Shikata

    Affiliation Research Institute for Health Fundamentals, Ajinomoto Co. Inc., Kawasaki, Kanagawa, Japan

    ⨯
  • Yoshiko Kimura,

    Affiliation Research Institute for Health Fundamentals, Ajinomoto Co. Inc., Kawasaki, Kanagawa, Japan

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  • Jose O. Aleman,

    Affiliation Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Jamey D. Young,

    Affiliation Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Naoto Koyama,

    Affiliation Research Institute for Health Fundamentals, Ajinomoto Co. Inc., Kawasaki, Kanagawa, Japan

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  • Joanne K. Kelleher,

    Affiliations Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Shriners Burn Hospital, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Michio Takahashi,

    Affiliation Research Institute for Health Fundamentals, Ajinomoto Co. Inc., Kawasaki, Kanagawa, Japan

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  • Gregory Stephanopoulos

    gregstep@mit.edu

    Affiliation Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    ⨯

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