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Open Access

Peer-reviewed

Research Article

Allele-Specific RNA Silencing of Mutant Ataxin-3 Mediates Neuroprotection in a Rat Model of Machado-Joseph Disease

  • Sandro Alves,

    Affiliations Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal, CEA, Institute of Molecular Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Orsay, France

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  • Isabel Nascimento-Ferreira,

    Affiliations Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal

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  • Gwennaëlle Auregan,

    Affiliations CEA, Institute of Molecular Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Orsay, France, CNRS URA 2210, Orsay, France

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  • Raymonde Hassig,

    Affiliations CEA, Institute of Molecular Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Orsay, France, CNRS URA 2210, Orsay, France

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  • Noëlle Dufour,

    Affiliations CEA, Institute of Molecular Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Orsay, France, CNRS URA 2210, Orsay, France

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  • Emmanuel Brouillet,

    Affiliations CEA, Institute of Molecular Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Orsay, France, CNRS URA 2210, Orsay, France

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  • Maria C. Pedroso de Lima,

    Affiliations Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal, Faculty of Sciences, University of Coimbra, Coimbra, Portugal

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  • Philippe Hantraye,

    Affiliations CEA, Institute of Molecular Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Orsay, France, CNRS URA 2210, Orsay, France

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  • Luís Pereira de Almeida ,

    Contributed equally to this work with: Luís Pereira de Almeida, Nicole Déglon

    luispa@cnc.uc.pt

    Affiliations Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal

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  • Nicole Déglon

    Contributed equally to this work with: Luís Pereira de Almeida, Nicole Déglon

    Affiliations CEA, Institute of Molecular Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Orsay, France, CNRS URA 2210, Orsay, France

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