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Research Article

Direct Evidence for Pitavastatin Induced Chromatin Structure Change in the KLF4 Gene in Endothelial Cells

  • Takashi Maejima equal contributor,

    equal contributor Contributed equally to this work with: Takashi Maejima, Tsuyoshi Inoue

    Affiliations: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

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  • Tsuyoshi Inoue equal contributor,

    equal contributor Contributed equally to this work with: Takashi Maejima, Tsuyoshi Inoue

    Affiliations: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Division of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Bunkyo-ku, Tokyo, Japan

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  • Yasuharu Kanki,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Takahide Kohro,

    Affiliations: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Department of Translational Research for Healthcare and Clinical Science, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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  • Guoliang Li,

    Affiliation: Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, United States of America

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  • Yoshihiro Ohta,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Hiroshi Kimura mail,

    hkimura@fbs.osaka-u.ac.jp (HK); kodama@lsbm.org (TK); ywada-tky@umin.ac.jp (YW)

    Affiliation: Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan

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  • Mika Kobayashi,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Akashi Taguchi,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Shuichi Tsutsumi,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Hiroko Iwanari,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Shogo Yamamoto,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Hirofumi Aruga,

    Affiliation: Thermo Fisher Scientific, South San Francisco, California, United States of America

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  • Shoulian Dong,

    Affiliation: Thermo Fisher Scientific, South San Francisco, California, United States of America

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  • Junko F. Stevens,

    Affiliation: Thermo Fisher Scientific, South San Francisco, California, United States of America

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  • Huay Mei Poh,

    Affiliation: Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, United States of America

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  • Kazuki Yamamoto,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Takeshi Kawamura,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Imari Mimura,

    Affiliations: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Division of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Bunkyo-ku, Tokyo, Japan

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  • Jun-ichi Suehiro,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Akira Sugiyama,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Kiyomi Kaneki,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Haruki Shibata,

    Affiliation: Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

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  • Yasunobu Yoshinaka,

    Affiliation: Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

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  • Takeshi Doi,

    Affiliation: Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

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  • Akimune Asanuma,

    Affiliation: Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

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  • Sohei Tanabe,

    Affiliation: Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

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  • Toshiya Tanaka,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Takashi Minami,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Takao Hamakubo,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Juro Sakai,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Naohito Nozaki,

    Affiliation: Mab Institute Inc., North Advancement Center for Science & Technology, Sapporo, Hokkaido, Japan

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  • Hiroyuki Aburatani,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Masaomi Nangaku,

    Affiliation: Division of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Bunkyo-ku, Tokyo, Japan

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  • Xiaoan Ruan,

    Affiliation: Genome Institute of Singapore, Singapore, Singapore

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  • Hideyuki Tanabe,

    Affiliation: Department of Evolutionary Studies of Biosystems, School of Advanced Sciences, The Graduate University for Advanced Studies (Sokendai), Hayama, Kanagawa, Japan

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  • Yijun Ruan,

    Affiliation: Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, United States of America

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  • Sigeo Ihara,

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Akira Endo,

    Affiliation: Biopharm Research Laboratories, Inc., Koganei, Tokyo, Japan

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  • Tatsuhiko Kodama mail,

    hkimura@fbs.osaka-u.ac.jp (HK); kodama@lsbm.org (TK); ywada-tky@umin.ac.jp (YW)

    Affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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  • Youichiro Wada mail

    hkimura@fbs.osaka-u.ac.jp (HK); kodama@lsbm.org (TK); ywada-tky@umin.ac.jp (YW)

    Affiliations: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Radioisotope Center, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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  • Published: May 05, 2014
  • DOI: 10.1371/journal.pone.0096005

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