The Mechanism of Intralipid®-Mediated Cardioprotection Complex IV Inhibition by the Active Metabolite, Palmitoylcarnitine, Generates Reactive Oxygen Species and Activates Reperfusion Injury Salvage Kinases

• Phing-How Lou,

  Affiliation Postdoctoral Fellow, Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada

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• Eliana Lucchinetti,

  Affiliation Research Associate, Department of Anesthesiology & Pain Medicine, University of Alberta, Edmonton, AB, Canada

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• Liyan Zhang,

  Affiliation Research Associate, Department of Anesthesiology & Pain Medicine, University of Alberta, Edmonton, AB, Canada

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• Andreas Affolter,

  Affiliation Research Associate, Department of Clinical Chemistry, University Children’s Hospital Zurich, Zurich, Switzerland

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• Marcus C. Schaub,

  Affiliation Professor, Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland

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• Manoj Gandhi,

  Affiliation Research Associate, Department of Pharmacology, University of Alberta, Edmonton, AB, Canada

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• Martin Hersberger,

  Affiliation Head of the Department of Clinical Chemistry, University Children’s Hospital Zurich, Zurich, Switzerland

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• Blair E. Warren,

  Affiliation Undergraduate student, Campus Saint-Jean, University of Alberta, Edmonton, AB, Canada

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• Hélène Lemieux,

  Affiliation Assistant Professor, Campus Saint-Jean, University of Alberta, Edmonton, AB, Canada

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• Hany F. Sobhi,

  Affiliation Assistant Professor and Director of Coppin Center for Organic Synthesis, Coppin State University, Baltimore, Maryland, United States of America

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• Alexander S. Clanachan ,

  Contributed equally to this work with: Alexander S. Clanachan, Michael Zaugg

  Affiliation Professor, Department of Pharmacology, University of Alberta, Edmonton, AB, Canada

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• Michael Zaugg

  Contributed equally to this work with: Alexander S. Clanachan, Michael Zaugg

  * E-mail: michael.zaugg@ualberta.ca

  Affiliation Professor, Department of Anesthesiology & Pain Medicine, University of Alberta, Edmonton, AB, Canada

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