Decreased Mutation Frequencies among Immunoglobulin G Variable Region Genes during Viremic HIV-1 Infection

Elisabeth Bowers; Ronald W. Scamurra; Anil Asrani; Lydie Beniguel; Samantha MaWhinney; Kathryne M. Keays; Joseph R. Thurn; Edward N. Janoff

doi:10.1371/journal.pone.0081913

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Peer-reviewed

Research Article

Decreased Mutation Frequencies among Immunoglobulin G Variable Region Genes during Viremic HIV-1 Infection

Elisabeth Bowers,

Affiliations Mucosal and Vaccine Research Program Colorado (MAVRC), University of Colorado Denver, Aurora, Colorado, United States of America, Infectious Disease Division, University of Colorado Denver, Aurora, Colorado, United States of America, Department of Microbiology, University of Colorado Denver, Aurora, Colorado, United States of America, Denver Veterans Affairs Medical Center, Denver, Colorado, United States of America
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Ronald W. Scamurra,

Affiliation Minneapolis VA Health Care System, University of Minnesota, Minneapolis, Minnesota, United States of America
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Anil Asrani,

Affiliation Minneapolis VA Health Care System, University of Minnesota, Minneapolis, Minnesota, United States of America
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Lydie Beniguel,

Affiliation GIMAP EA 3064, Faculté de Médecine, Université Jean Monnet, Saint Etienne, France
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Samantha MaWhinney,

Affiliations Mucosal and Vaccine Research Program Colorado (MAVRC), University of Colorado Denver, Aurora, Colorado, United States of America, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, United States of America
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Kathryne M. Keays,

Affiliations Mucosal and Vaccine Research Program Colorado (MAVRC), University of Colorado Denver, Aurora, Colorado, United States of America, Infectious Disease Division, University of Colorado Denver, Aurora, Colorado, United States of America
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Joseph R. Thurn,

Affiliation Minneapolis VA Health Care System, University of Minnesota, Minneapolis, Minnesota, United States of America
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Edward N. Janoff

* , e-mail:Edward.Janoff@ucdenver.edu

Affiliations Mucosal and Vaccine Research Program Colorado (MAVRC), University of Colorado Denver, Aurora, Colorado, United States of America, Infectious Disease Division, University of Colorado Denver, Aurora, Colorado, United States of America, Department of Microbiology, University of Colorado Denver, Aurora, Colorado, United States of America, Denver Veterans Affairs Medical Center, Denver, Colorado, United States of America
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Decreased Mutation Frequencies among Immunoglobulin G Variable Region Genes during Viremic HIV-1 Infection

Elisabeth Bowers,
Ronald W. Scamurra,
Anil Asrani,
Lydie Beniguel,
Samantha MaWhinney,
Kathryne M. Keays,
Joseph R. Thurn,
Edward N. Janoff

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Published: January 7, 2014
https://doi.org/10.1371/journal.pone.0081913

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HIV-1
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Nucleotides
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B cells
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Nucleotide sequencing
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Amino acid substitution
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Gene expression
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