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Open Access

Peer-reviewed

Research Article

A Role for Cytosolic Isocitrate Dehydrogenase as a Negative Regulator of Glucose Signaling for Insulin Secretion in Pancreatic ß-Cells

  • Claudiane Guay ,

    Contributed equally to this work with: Claudiane Guay, Érik Joly

    Affiliation Molecular Nutrition Unit and the Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l'Université de Montréal, CR-CHUM, Montreal, Quebec, Canada

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  • Érik Joly ,

    Contributed equally to this work with: Claudiane Guay, Érik Joly

    Affiliation Molecular Nutrition Unit and the Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l'Université de Montréal, CR-CHUM, Montreal, Quebec, Canada

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  • Émilie Pepin,

    Affiliation Molecular Nutrition Unit and the Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l'Université de Montréal, CR-CHUM, Montreal, Quebec, Canada

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  • Annie Barbeau,

    Affiliation Molecular Nutrition Unit and the Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l'Université de Montréal, CR-CHUM, Montreal, Quebec, Canada

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  • Lisa Hentsch,

    Affiliation Molecular Nutrition Unit and the Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l'Université de Montréal, CR-CHUM, Montreal, Quebec, Canada

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  • Marco Pineda,

    Affiliation Molecular Nutrition Unit and the Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l'Université de Montréal, CR-CHUM, Montreal, Quebec, Canada

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  • S. R. Murthy Madiraju,

    Affiliation Molecular Nutrition Unit and the Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l'Université de Montréal, CR-CHUM, Montreal, Quebec, Canada

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  • Henri Brunengraber,

    Affiliation Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United State of America

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  • Marc Prentki

    marc.prentki@umontreal.ca

    Affiliations Molecular Nutrition Unit and the Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l'Université de Montréal, CR-CHUM, Montreal, Quebec, Canada, Departments of Nutrition and Biochemistry, University of Montreal, Montreal, Quebec, Canada

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