An Intragenic SRF-Dependent Regulatory Motif Directs Cardiac-Specific microRNA-1-1/133a-2 Expression

Qi Li; Junli Guo; Xi Lin; Xiangsheng Yang; Yanlin Ma; Guo-Chang Fan; Jiang Chang

doi:10.1371/journal.pone.0075470

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Peer-reviewed

Research Article

An Intragenic SRF-Dependent Regulatory Motif Directs Cardiac-Specific microRNA-1-1/133a-2 Expression

Qi Li ,

Contributed equally to this work with: Qi Li, Junli Guo

Affiliation Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Cardiovascular Disease and Research Institute, Affiliated Hospital of Hainan Medical College, Haikou, Hainan, China
⨯
Junli Guo ,

Contributed equally to this work with: Qi Li, Junli Guo

Affiliations Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Cardiovascular Disease and Research Institute, Affiliated Hospital of Hainan Medical College, Haikou, Hainan, China, Hainan Provincial Key Laboratory of Tropical Medicine, Hainan Medical College, Haikou, Hainan, China
⨯
Xi Lin,

Affiliation Texas A&M University Health Science Center, Institute of Biosciences and Technology, Houston, Texas, United States of America
⨯
Xiangsheng Yang,

Affiliation Texas A&M University Health Science Center, Institute of Biosciences and Technology, Houston, Texas, United States of America
⨯
Yanlin Ma,

Affiliation Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Cardiovascular Disease and Research Institute, Affiliated Hospital of Hainan Medical College, Haikou, Hainan, China
⨯
Guo-Chang Fan,

Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Jiang Chang

* E-mail: jchang@ibt.tamhsc.edu

Affiliation Texas A&M University Health Science Center, Institute of Biosciences and Technology, Houston, Texas, United States of America
⨯

An Intragenic SRF-Dependent Regulatory Motif Directs Cardiac-Specific microRNA-1-1/133a-2 Expression

Qi Li,
Junli Guo,
Xi Lin,
Xiangsheng Yang,
Yanlin Ma,
Guo-Chang Fan,
Jiang Chang

x

Published: September 13, 2013
https://doi.org/10.1371/journal.pone.0075470

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Gene expression
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Gene regulation
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Skeletal muscles
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Chromatin immunoprecipitation
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Transcriptional control
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Heart
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MicroRNAs
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Sequence motif analysis
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