Global Substrate Profiling of Proteases in Human Neutrophil Extracellular Traps Reveals Consensus Motif Predominantly Contributed by Elastase

• Anthony J. O’Donoghue ,

  Contributed equally to this work with: Anthony J. O’Donoghue, Ye Jin

  Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, California, United States of America

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• Ye Jin ,

  Contributed equally to this work with: Anthony J. O’Donoghue, Ye Jin

  Affiliation US Innovation Center, Bayer Healthcare Pharmaceuticals, San Francisco, California, United States of America

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• Giselle M. Knudsen,

  Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, California, United States of America

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• Natascha C. Perera,

  Affiliation Comprehensive Pneumology Center, Institute of Lung Biology and Disease (ILBD), Helmholtz Zentrum München, Member of the German Center for Lung Research, Munich, Germany

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• Dieter E. Jenne,

  Affiliations Comprehensive Pneumology Center, Institute of Lung Biology and Disease (ILBD), Helmholtz Zentrum München, Member of the German Center for Lung Research, Munich, Germany, Max-Planck-Institute of Neurobiology, Planegg-Martinsried, Germany

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• John E. Murphy,

  Affiliation US Innovation Center, Bayer Healthcare Pharmaceuticals, San Francisco, California, United States of America

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• Charles S. Craik,

  Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, California, United States of America

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• Terry W. Hermiston

  * E-mail: Terry.Hermiston@bayer.com

  Affiliation US Innovation Center, Bayer Healthcare Pharmaceuticals, San Francisco, California, United States of America

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