A Small-Animal Pharmacokinetic/Pharmacodynamic PET Study of Central Serotonin 1A Receptor Occupancy by a Potential Therapeutic Agent for Overactive Bladder

• Yosuke Nakatani,

  Affiliations Tsukuba Research Laboratories, Eisai Co, Ltd., Tsukuba, Ibaraki, Japan, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba, Japan, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan

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• Michiyuki Suzuki,

  Affiliations Tsukuba Research Laboratories, Eisai Co, Ltd., Tsukuba, Ibaraki, Japan, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba, Japan

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• Masaki Tokunaga,

  Affiliation Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba, Japan

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• Jun Maeda,

  Affiliation Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba, Japan

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• Miyuki Sakai,

  Affiliation Tsukuba Research Laboratories, Eisai Co, Ltd., Tsukuba, Ibaraki, Japan

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• Hiroki Ishihara,

  Affiliation Tsukuba Research Laboratories, Eisai Co, Ltd., Tsukuba, Ibaraki, Japan

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• Takashi Yoshinaga,

  Affiliation Tsukuba Research Laboratories, Eisai Co, Ltd., Tsukuba, Ibaraki, Japan

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• Osamu Takenaka,

  Affiliation Tsukuba Research Laboratories, Eisai Co, Ltd., Tsukuba, Ibaraki, Japan

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• Ming-Rong Zhang,

  Affiliations Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba, Japan, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan

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• Tetsuya Suhara,

  Affiliations Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba, Japan, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan

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• Makoto Higuchi

  * E-mail: mhiguchi@nirs.go.jp

  Affiliations Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba, Japan, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan

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